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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2007-10-25
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pubmed:abstractText |
The beta3-adrenergic receptor (ADRB3) is a transmembrane receptor highly expressed in adipose tissue and thought to be involved in the regulation of lipolysis. ADRB3 is also highly expressed in gallbladder tissue where it may be involved in gallbladder contraction. Because polymorphisms of ADRB3 are present in populations with a high prevalence of gallstones (e.g., Pima-Indians, obese subjects), we hypothesized that known polymorphisms for ADRB3 (Trp64Arg) may represent an independent risk factor for gallstone disease.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0002-9270
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
102
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2482-7
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pubmed:meshHeading |
pubmed-meshheading:17640319-Arginine,
pubmed-meshheading:17640319-Body Mass Index,
pubmed-meshheading:17640319-Cross-Sectional Studies,
pubmed-meshheading:17640319-DNA Mutational Analysis,
pubmed-meshheading:17640319-Female,
pubmed-meshheading:17640319-Gallstones,
pubmed-meshheading:17640319-Gene Frequency,
pubmed-meshheading:17640319-Genetic Predisposition to Disease,
pubmed-meshheading:17640319-Genotype,
pubmed-meshheading:17640319-Germany,
pubmed-meshheading:17640319-Humans,
pubmed-meshheading:17640319-Logistic Models,
pubmed-meshheading:17640319-Male,
pubmed-meshheading:17640319-Middle Aged,
pubmed-meshheading:17640319-Mutation, Missense,
pubmed-meshheading:17640319-Polymorphism, Genetic,
pubmed-meshheading:17640319-Receptors, Adrenergic, beta-3,
pubmed-meshheading:17640319-Tryptophan
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pubmed:year |
2007
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pubmed:articleTitle |
Arg64 variant of the beta3-adrenergic receptor is associated with gallstone formation.
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pubmed:affiliation |
Department of Internal Medicine I, University Hospital Ulm, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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