pubmed-article:17640161 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:17640161 | lifeskim:mentions | umls-concept:C0021853 | lld:lifeskim |
pubmed-article:17640161 | lifeskim:mentions | umls-concept:C1326912 | lld:lifeskim |
pubmed-article:17640161 | lifeskim:mentions | umls-concept:C0006726 | lld:lifeskim |
pubmed-article:17640161 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
pubmed-article:17640161 | lifeskim:mentions | umls-concept:C1545588 | lld:lifeskim |
pubmed-article:17640161 | pubmed:issue | 2 | lld:pubmed |
pubmed-article:17640161 | pubmed:dateCreated | 2007-7-20 | lld:pubmed |
pubmed-article:17640161 | pubmed:abstractText | Although high-calcium diets have been reported to reduce the risk of colorectal cancer, our preliminary data with the adenomatous polyposis coli (Apc) Min mutation (Min/+;Apc(Min/+)) mouse shows a paradoxical increase in intestinal tumor loads (> 65%) with high calcium diets. Since we previously demonstrated that increasing dietary calcium reduces adiposity, and Apc(Min/+) mice on high calcium diets exhibited profound loss of adipose tissue, we hypothesized that loss of an adipose tissue-derived tumor suppressor factor(s) resulted in increased tumor susceptibility in animals on the high calcium diet. Accordingly, tumor prone Apc(Min/+) mice were crossed with obesity prone lethal yellow agouti (A(y)/a) mice to generate obese A(y)/Apc(Min/+) mice. Low (0.2%), normal (0.5%), and high (1.2%) calcium diets were fed to both A(y)/Apc(Min/+) mice and Apc(Min/+) mice from 35-40 days until 90 days of age (n=21/strain, n=7/diet group). The high calcium diet reduced weight gain in both strains (P < 0.01) and reduced fat pad mass by 46-57% in A(y)/Apc(Min/+)(P < 0.004) and by 65-82% in Apc(Min/+)(P < 0.03).Apc(Min/+) mice on the high calcium diet exhibited an increase in tumor number (76 vs. 29, P=0.009), but this effect was not seen in the A(y)/Apc(Min/+) mice. beta-Catenin and cyclin D1 gene expression were significantly induced with high calcium diet in intestinal tumor tissue of Apc(Min/+) mice but not in A(y)/Apc(Min/+) mice. We conclude that the differential effect of dietary calcium on intestinal tumorigenesis in lean vs. obese Apc(Min/+) may result from the loss of adipose-derived protective factor(s) due to the substantial loss of body fat in Apc(Min/+) mice fed a high calcium dairy diet, increasing beta-catenin and cyclin D1 in tumors. | lld:pubmed |
pubmed-article:17640161 | pubmed:language | eng | lld:pubmed |
pubmed-article:17640161 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17640161 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:17640161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17640161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17640161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17640161 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:17640161 | pubmed:issn | 0163-5581 | lld:pubmed |
pubmed-article:17640161 | pubmed:author | pubmed-author:ZemekLL | lld:pubmed |
pubmed-article:17640161 | pubmed:author | pubmed-author:WhelanJJ | lld:pubmed |
pubmed-article:17640161 | pubmed:author | pubmed-author:McEnteeM FMF | lld:pubmed |
pubmed-article:17640161 | pubmed:author | pubmed-author:DingSS | lld:pubmed |
pubmed-article:17640161 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:17640161 | pubmed:volume | 58 | lld:pubmed |
pubmed-article:17640161 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:17640161 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:17640161 | pubmed:pagination | 153-61 | lld:pubmed |
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pubmed-article:17640161 | pubmed:year | 2007 | lld:pubmed |
pubmed-article:17640161 | pubmed:articleTitle | Adiposity-related protection of intestinal tumorigenesis: interaction with dietary calcium. | lld:pubmed |
pubmed-article:17640161 | pubmed:affiliation | Department of Nutrition, University of Tennessee, Knoxville, TN 37996-1920, USA. | lld:pubmed |
pubmed-article:17640161 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:17640161 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
entrez-gene:11789 | entrezgene:pubmed | pubmed-article:17640161 | lld:entrezgene |
entrez-gene:50518 | entrezgene:pubmed | pubmed-article:17640161 | lld:entrezgene |