Source:http://linkedlifedata.com/resource/pubmed/id/17640161
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2007-7-20
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pubmed:abstractText |
Although high-calcium diets have been reported to reduce the risk of colorectal cancer, our preliminary data with the adenomatous polyposis coli (Apc) Min mutation (Min/+;Apc(Min/+)) mouse shows a paradoxical increase in intestinal tumor loads (> 65%) with high calcium diets. Since we previously demonstrated that increasing dietary calcium reduces adiposity, and Apc(Min/+) mice on high calcium diets exhibited profound loss of adipose tissue, we hypothesized that loss of an adipose tissue-derived tumor suppressor factor(s) resulted in increased tumor susceptibility in animals on the high calcium diet. Accordingly, tumor prone Apc(Min/+) mice were crossed with obesity prone lethal yellow agouti (A(y)/a) mice to generate obese A(y)/Apc(Min/+) mice. Low (0.2%), normal (0.5%), and high (1.2%) calcium diets were fed to both A(y)/Apc(Min/+) mice and Apc(Min/+) mice from 35-40 days until 90 days of age (n=21/strain, n=7/diet group). The high calcium diet reduced weight gain in both strains (P < 0.01) and reduced fat pad mass by 46-57% in A(y)/Apc(Min/+)(P < 0.004) and by 65-82% in Apc(Min/+)(P < 0.03).Apc(Min/+) mice on the high calcium diet exhibited an increase in tumor number (76 vs. 29, P=0.009), but this effect was not seen in the A(y)/Apc(Min/+) mice. beta-Catenin and cyclin D1 gene expression were significantly induced with high calcium diet in intestinal tumor tissue of Apc(Min/+) mice but not in A(y)/Apc(Min/+) mice. We conclude that the differential effect of dietary calcium on intestinal tumorigenesis in lean vs. obese Apc(Min/+) may result from the loss of adipose-derived protective factor(s) due to the substantial loss of body fat in Apc(Min/+) mice fed a high calcium dairy diet, increasing beta-catenin and cyclin D1 in tumors.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0163-5581
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
58
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
153-61
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pubmed:meshHeading |
pubmed-meshheading:17640161-Adiposity,
pubmed-meshheading:17640161-Animals,
pubmed-meshheading:17640161-Calcium, Dietary,
pubmed-meshheading:17640161-Colorectal Neoplasms,
pubmed-meshheading:17640161-Cyclin D1,
pubmed-meshheading:17640161-Dose-Response Relationship, Drug,
pubmed-meshheading:17640161-Germ-Line Mutation,
pubmed-meshheading:17640161-Intestinal Neoplasms,
pubmed-meshheading:17640161-Intestines,
pubmed-meshheading:17640161-Male,
pubmed-meshheading:17640161-Mice,
pubmed-meshheading:17640161-Mice, Inbred C57BL,
pubmed-meshheading:17640161-Mice, Mutant Strains,
pubmed-meshheading:17640161-Mice, Obese,
pubmed-meshheading:17640161-Random Allocation,
pubmed-meshheading:17640161-Weight Gain,
pubmed-meshheading:17640161-beta Catenin
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pubmed:year |
2007
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pubmed:articleTitle |
Adiposity-related protection of intestinal tumorigenesis: interaction with dietary calcium.
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pubmed:affiliation |
Department of Nutrition, University of Tennessee, Knoxville, TN 37996-1920, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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