Linked Life Data

17639725

Source:http://linkedlifedata.com/resource/pubmed/id/17639725

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2007-7-20
pubmed:abstractText
Novel synthetic oxysterols (22S,23S)-3beta-hydroxy-22,23-oxido-5alpha-ergost-8(14)-en-15-one (I) and (22R,23R)-33-hydroxy-22,23-oxido-5alpha-ergost-8(14)-en-15-one (II) efficiently inhibited cholesterol biosynthesis in human hepatoma Hep G2 cell line at a short time incubation in a serum free medium (IC50 = 1.9 +/- 0.2 and 0.6 +/- 0.2 microM, respectively). Cultivation of Hep G2 cells in the presence of compound 5 microM concentration of both (1) and (II), led to significant depression of cholesterol biosynthesis (52% and 57% from control), and remarkable changes in fatty acids, triglycerides, and cholesteryl esters biosynthesis. Compounds (I) and (II) stimulated transformation of exogeneous cholesterol to polar products secreted into the culture medium (156% and 175% from control), that was shown in experiments in Hep G2 cells prelabeled with [3H]cholesterol.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:author
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
221-7
pubmed:dateRevised
2008-4-3
pubmed:meshHeading
pubmed:articleTitle
[Effects of (22S,23S)-3beta-hydroxy-22,23-oxido-5alpha-ergost-8(14)-en-15-one and (22R,23R)-3beta-hydroxy-22,23-oxido-5alpha-ergost-8(14)-en-15-one on lipid biosynthesis and exogeneous cholesterol metabolism in hep G2 cells].
pubmed:publicationType
Journal Article, English Abstract