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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1976-6-2
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pubmed:abstractText |
White Leghorn chickens congenitally infected with a subgroup A avian leukosis virus ALV-F42 were challenged at various ages with the serologically related subgroup A avian leukosis viruses (ALV) RAV-1, RAV-3, and RAV-5 and their antibody responses and viremic status determined. Birds given injections of RAV-1 failed to produce neutralizing antibody to any of the pseudotype sarcoma viruses of the various ALV, whereas many birds challenged with RAV-3 or RAV-5 produced neutralizing antibody directed against the heterologous RAV-1 as well as the homologous viruses, but not against the tolerated virus ALV-F42. Virtually all birds remained viremic despite the presence of neutralizing antibody. The results suggested that a phenomenon akin to circumvention or abrogation of tolerance to ALV-F42 was effected, and that there are multiple determinants of the viral envelope antigens of ALV as measured by neutralization.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0027-8874
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
381-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:176386-Age Factors,
pubmed-meshheading:176386-Animals,
pubmed-meshheading:176386-Antibodies, Viral,
pubmed-meshheading:176386-Antibody Formation,
pubmed-meshheading:176386-Antigens, Viral,
pubmed-meshheading:176386-Avian leukosis virus,
pubmed-meshheading:176386-Chickens,
pubmed-meshheading:176386-Cross Reactions,
pubmed-meshheading:176386-Immune Tolerance,
pubmed-meshheading:176386-Neutralization Tests
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pubmed:year |
1976
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pubmed:articleTitle |
Antibody response to related leukosis viruses induced in chickens tolerant to an avian leukosis virus.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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