| pubmed-article:17637170 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17637170 | lifeskim:mentions | umls-concept:C0567416 | lld:lifeskim |
| pubmed-article:17637170 | lifeskim:mentions | umls-concept:C0450254 | lld:lifeskim |
| pubmed-article:17637170 | lifeskim:mentions | umls-concept:C0205198 | lld:lifeskim |
| pubmed-article:17637170 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:17637170 | pubmed:dateCreated | 2007-7-19 | lld:pubmed |
| pubmed-article:17637170 | pubmed:abstractText | Anti-adhesive compounds are potential prophylactic tools in alternative treatment regimes against bacterial infection, as bacterial adhesion is commonly mediated by carbohydrate-protein interactions between surface adhesions of microorganisms and the host cell. The use of exogenous polyvalent, high-molecular carbohydrates and tannin-like plant-derived compounds should antagonize the adhesive interaction. A range of carbohydrates and carbohydrate- and proanthocyanidin-enriched plant extracts were screened for potential anti-adhesive effects against Helicobacter pylori, Campylobacter jejuni, Porphyromonas gingivalis and Candida albicans in different in-situ assays on primary tissue. The adhesion of H. pylori on human stomach tissue was effectively blocked by glucuronic acid-enriched polysaccharides from immature okra fruits (Abelmoschus esculentus). These compounds also had strong in-vitro effects against C. jejuni (inhibition up to 80%), but were ineffective in an in-vivo study in infected chicken broilers due to metabolism in the gastrointestinal system. Polysaccharides from Glycyrrhizia glabra, also enriched with glucuronic acid, showed strong anti-adhesive properties against H. pylori and P. gingivalis (inhibition 60-70%). Pelargonium sidoides extract, containing mainly polymeric proanthocyanidins, was effective against H. pylori in a dose-dependent manner. Due to the multifunctional adhesive strategy of C. albicans, no effective compounds were detected against this yeast. Structure-activity relationships are presented and the potential in-vivo use of carbohydrate-based anti-adhesives is discussed. | lld:pubmed |
| pubmed-article:17637170 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17637170 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17637170 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17637170 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17637170 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17637170 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17637170 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17637170 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17637170 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17637170 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17637170 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:17637170 | pubmed:issn | 0022-3573 | lld:pubmed |
| pubmed-article:17637170 | pubmed:author | pubmed-author:VerspohlE JEJ | lld:pubmed |
| pubmed-article:17637170 | pubmed:author | pubmed-author:ErnstJ FJF | lld:pubmed |
| pubmed-article:17637170 | pubmed:author | pubmed-author:HenselAA | lld:pubmed |
| pubmed-article:17637170 | pubmed:author | pubmed-author:StratmannUU | lld:pubmed |
| pubmed-article:17637170 | pubmed:author | pubmed-author:LengsfeldCC | lld:pubmed |
| pubmed-article:17637170 | pubmed:author | pubmed-author:WittschierNN | lld:pubmed |
| pubmed-article:17637170 | pubmed:author | pubmed-author:VorthemsSS | lld:pubmed |
| pubmed-article:17637170 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17637170 | pubmed:volume | 59 | lld:pubmed |
| pubmed-article:17637170 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17637170 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17637170 | pubmed:pagination | 777-86 | lld:pubmed |
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| pubmed-article:17637170 | pubmed:meshHeading | pubmed-meshheading:17637170... | lld:pubmed |
| pubmed-article:17637170 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17637170 | pubmed:articleTitle | Large molecules as anti-adhesive compounds against pathogens. | lld:pubmed |
| pubmed-article:17637170 | pubmed:affiliation | University of Münster, Institute for Pharmaceutical Biology and Phytochemistry, Hittorfstrasse 56, D-48149 Münster, Germany. | lld:pubmed |
| pubmed-article:17637170 | pubmed:publicationType | Journal Article | lld:pubmed |
