Source:http://linkedlifedata.com/resource/pubmed/id/17637170
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2007-7-19
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| pubmed:abstractText |
Anti-adhesive compounds are potential prophylactic tools in alternative treatment regimes against bacterial infection, as bacterial adhesion is commonly mediated by carbohydrate-protein interactions between surface adhesions of microorganisms and the host cell. The use of exogenous polyvalent, high-molecular carbohydrates and tannin-like plant-derived compounds should antagonize the adhesive interaction. A range of carbohydrates and carbohydrate- and proanthocyanidin-enriched plant extracts were screened for potential anti-adhesive effects against Helicobacter pylori, Campylobacter jejuni, Porphyromonas gingivalis and Candida albicans in different in-situ assays on primary tissue. The adhesion of H. pylori on human stomach tissue was effectively blocked by glucuronic acid-enriched polysaccharides from immature okra fruits (Abelmoschus esculentus). These compounds also had strong in-vitro effects against C. jejuni (inhibition up to 80%), but were ineffective in an in-vivo study in infected chicken broilers due to metabolism in the gastrointestinal system. Polysaccharides from Glycyrrhizia glabra, also enriched with glucuronic acid, showed strong anti-adhesive properties against H. pylori and P. gingivalis (inhibition 60-70%). Pelargonium sidoides extract, containing mainly polymeric proanthocyanidins, was effective against H. pylori in a dose-dependent manner. Due to the multifunctional adhesive strategy of C. albicans, no effective compounds were detected against this yeast. Structure-activity relationships are presented and the potential in-vivo use of carbohydrate-based anti-adhesives is discussed.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Bacterial Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antifungal Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Carbohydrates,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Extracts,
http://linkedlifedata.com/resource/pubmed/chemical/Polysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Proanthocyanidins
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
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| pubmed:issn |
0022-3573
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
59
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
777-86
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| pubmed:meshHeading |
pubmed-meshheading:17637170-Abelmoschus,
pubmed-meshheading:17637170-Animals,
pubmed-meshheading:17637170-Anti-Bacterial Agents,
pubmed-meshheading:17637170-Antifungal Agents,
pubmed-meshheading:17637170-Bacterial Adhesion,
pubmed-meshheading:17637170-Campylobacter jejuni,
pubmed-meshheading:17637170-Candida albicans,
pubmed-meshheading:17637170-Carbohydrates,
pubmed-meshheading:17637170-Chickens,
pubmed-meshheading:17637170-Gastric Mucosa,
pubmed-meshheading:17637170-Glycyrrhiza,
pubmed-meshheading:17637170-Helicobacter pylori,
pubmed-meshheading:17637170-Humans,
pubmed-meshheading:17637170-Pelargonium,
pubmed-meshheading:17637170-Plant Extracts,
pubmed-meshheading:17637170-Polysaccharides,
pubmed-meshheading:17637170-Porphyromonas gingivalis,
pubmed-meshheading:17637170-Proanthocyanidins,
pubmed-meshheading:17637170-Rats,
pubmed-meshheading:17637170-Structure-Activity Relationship
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| pubmed:year |
2007
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| pubmed:articleTitle |
Large molecules as anti-adhesive compounds against pathogens.
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| pubmed:affiliation |
University of Münster, Institute for Pharmaceutical Biology and Phytochemistry, Hittorfstrasse 56, D-48149 Münster, Germany.
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| pubmed:publicationType |
Journal Article
|