Linked Life Data

17636385

Source:http://linkedlifedata.com/resource/pubmed/id/17636385

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2007-9-27
pubmed:abstractText
The effects of polysaccharide-based tissue adhesives on cell survival and inflammatory cell activation were determined using in vitro mouse cell cultures. Cytotoxicity of tissue adhesives was evaluated by placing adhesives in direct contact with 3T3 fibroblast cells. Polysaccharide-based tissue adhesives composed of dextran aldehyde and star PEG amine were non-cytotoxic to fibroblasts; in contrast, a commercial adhesive composed of 2-octyl cyanoacrylate was highly cytotoxic to fibroblasts. The inflammatory potential of tissue adhesives was evaluated by exposing J774 macrophage cells to adhesives, and measuring TNF-alpha release from macrophages. Polysaccharide-based tissue adhesives did not elicit inflammatory TNF-alpha release from macrophages. These results suggest that polysaccharide-based tissue adhesives are non-cytotoxic and non-inflammatory; the results are therefore significant in the design of in vitro cell culture systems to study biomaterials.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0141-5492
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1645-9
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Interactions of polysaccharide-based tissue adhesives with clinically relevant fibroblast and macrophage cell lines.
pubmed:affiliation
Biochemical Sciences and Engineering, Central Research and Development, DuPont Experimental Station, Wilmington, DE, 19880, USA. sujata.k.bhatia@usa.dupont.com
pubmed:publicationType
Journal Article