Linked Life Data

17636044

Source:http://linkedlifedata.com/resource/pubmed/id/17636044

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2007-9-19
pubmed:abstractText
G proteins are key intermediates in cellular signaling and act in response to a variety of extracellular stimuli. The prevailing paradigm is that G protein subunits form a heterotrimeric complex and function principally at the plasma membrane. However, there is growing evidence for localization at, and signaling by, G proteins at intracellular compartments. Moreover, different cellular pools of G proteins may be composed of distinct subunit subtypes, including some binding partners that function in the place of G protein gamma subunits. An article in this issue of Molecular Pharmacology (Yost et al., p. 812) describes the use of an innovative fluorescent cell imaging technique to study interactions of the G protein beta(5) subunit with a panel of Ggamma subunits as well as regulator of G protein signaling (RGS) proteins that contain a Ggamma-like subdomain. The approach used here provides a new strategy to elucidate the spatial and temporal properties of G proteins, including a growing number of atypical Gbetagamma pairings.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0026-895X
pubmed:author
pubmed:issnType
Print
pubmed:volume
72
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
810-1
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Illuminating Gbeta5 signaling.
pubmed:affiliation
Department of Biochemistry & Biophysics, University of North Carolina at Chapel Hill, 116 Manning Dr., CB 7260, Chapel Hill, NC 27599, USA.
pubmed:publicationType
Journal Article, Comment