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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
14
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pubmed:dateCreated |
2007-7-19
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pubmed:abstractText |
MDM2 is a major negative regulator of p53, and a single nucleotide polymorphism in the MDM2 promoter region SNP309 (rs2279744) has been shown to increase the affinity of the transcriptional activator Sp1, resulting in elevated MDM2 transcription and expression in some cancers. There is currently no information about the role of MDM2 polymorphism in renal cell carcinoma (RCC). We investigated polymorphisms in p53-related genes, including MDM2, and their interactions in renal cancer.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4123-9
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:17634539-Aged,
pubmed-meshheading:17634539-Carcinoma, Renal Cell,
pubmed-meshheading:17634539-Female,
pubmed-meshheading:17634539-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:17634539-Genetic Predisposition to Disease,
pubmed-meshheading:17634539-Genotype,
pubmed-meshheading:17634539-Humans,
pubmed-meshheading:17634539-Kidney Neoplasms,
pubmed-meshheading:17634539-Male,
pubmed-meshheading:17634539-Middle Aged,
pubmed-meshheading:17634539-Polymorphism, Single Nucleotide,
pubmed-meshheading:17634539-Prognosis,
pubmed-meshheading:17634539-Proto-Oncogene Proteins c-mdm2,
pubmed-meshheading:17634539-Risk Factors,
pubmed-meshheading:17634539-Survival Analysis,
pubmed-meshheading:17634539-Transcription, Genetic,
pubmed-meshheading:17634539-Tumor Suppressor Protein p53
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pubmed:year |
2007
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pubmed:articleTitle |
MDM2 SNP309 polymorphism as risk factor for susceptibility and poor prognosis in renal cell carcinoma.
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pubmed:affiliation |
Department of Urology, San Francisco Veterans Affairs Medical Center and University of California at San Francisco, San Francisco, California 94121, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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