Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2007-7-19
pubmed:abstractText
ErbB-3, an ErbB receptor tyrosine kinase, has been implicated in the pathogenesis of several malignancies, including prostate cancer. We found that ErbB-3 expression was up-regulated in prostate cancer cells within lymph node and bone metastases. Despite being a plasma membrane protein, ErbB-3 was also detected in the nuclei of the prostate cancer cells in the metastatic specimens. Because most metastatic specimens were from men who had undergone androgen ablation, we examined the primary tumors from patients who have undergone hormone deprivation therapy and found that a significant fraction of these specimens showed nuclear localization of ErbB3. We thus assessed the effect of androgens and the bone microenvironment on the nuclear translocation of ErbB-3 by using xenograft tumor models generated from bone-derived prostate cancer cell lines, MDA PCa 2b, and PC-3. In subcutaneous tumors, ErbB-3 was predominantly in the membrane/cytoplasm; however, it was present in the nuclei of the tumor cells in the femur. Castration of mice bearing subcutaneous MDA PCa 2b tumors induced a transient nuclear translocation of ErbB-3, with relocalization to the membrane/cytoplasm upon tumor recurrence. These findings suggest that the bone microenvironment and androgen status influence the subcellular localization of ErbB-3 in prostate cancer cells. We speculate that nuclear localization of ErbB-3 may aid prostate cancer cell survival during androgen ablation and progression of prostate cancer in bone.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-10095121, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-10344214, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-10682683, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-10744726, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-10944525, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-11324501, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-11454720, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-11533659, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-11546794, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-11679632, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-12045181, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-12165860, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-12209129, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-12548574, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-12648669, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-12778135, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-12807903, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-12840049, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-12855635, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-1372662, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-14607217, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-14735192, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-14991762, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-15380516, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-15534001, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-15950906, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-15994225, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-16299810, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-16314522, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-16552725, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-16675564, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-2687875, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-447482, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-7538656, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-7656248, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-7913137, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-7945309, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-8168083, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-8318694, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-9052472, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-9072304, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-9127320, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-9208852, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-9362517, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-9815652, http://linkedlifedata.com/resource/pubmed/commentcorrection/17634423-9823984
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1541-7786
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
675-84
pubmed:dateRevised
2011-9-26
pubmed:meshHeading
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