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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2007-7-16
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pubmed:abstractText |
The hypothesis that brain-derived neurotrophic factor (BDNF) is involved in the pathogenesis of major depression is supported by several research findings; however, genetic studies assessing the relationship between BDNF and psychiatric disorders have produced conflicting results. We examined the effect of a BDNF polymorphism on depression susceptibility in Mexican-Americans. The single nucleotide polymorphism (Val66Met), which has been shown to have functional and behavioral effects, was genotyped in 284 depressed participants and 331 controls, showing association with depression (P=0.005). Individuals homozygous for the major allele (GG) had an increased chance of being depressed (OR=1.7 95% CI 1.17-2.47). Our findings support the association of BDNF single nucleotide polymorphism rs6265 and depression, suggesting that this polymorphism may increase susceptibility to major depression in Mexican-Americans.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17632285-11522260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17632285-11927139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17632285-11943826,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17632285-12553913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17632285-14582140,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17632285-14609502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17632285-14673216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17632285-15537879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17632285-16005437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17632285-16343697,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17632285-16497333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17632285-16631126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17632285-16680163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17632285-17023662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17632285-7472505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17632285-8981620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17632285-9773357
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0959-4965
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1291-3
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17632285-Adult,
pubmed-meshheading:17632285-Amino Acid Substitution,
pubmed-meshheading:17632285-Brain,
pubmed-meshheading:17632285-Brain Chemistry,
pubmed-meshheading:17632285-Brain-Derived Neurotrophic Factor,
pubmed-meshheading:17632285-DNA Mutational Analysis,
pubmed-meshheading:17632285-Depressive Disorder,
pubmed-meshheading:17632285-Female,
pubmed-meshheading:17632285-Gene Frequency,
pubmed-meshheading:17632285-Genetic Markers,
pubmed-meshheading:17632285-Genetic Predisposition to Disease,
pubmed-meshheading:17632285-Genetic Testing,
pubmed-meshheading:17632285-Genotype,
pubmed-meshheading:17632285-Homozygote,
pubmed-meshheading:17632285-Humans,
pubmed-meshheading:17632285-Male,
pubmed-meshheading:17632285-Methionine,
pubmed-meshheading:17632285-Mexican Americans,
pubmed-meshheading:17632285-Middle Aged,
pubmed-meshheading:17632285-Polymorphism, Genetic,
pubmed-meshheading:17632285-Polymorphism, Single Nucleotide,
pubmed-meshheading:17632285-Valine
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pubmed:year |
2007
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pubmed:articleTitle |
The brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism and depression in Mexican-Americans.
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pubmed:affiliation |
Department of Psychiatry & Behavioral Sciences, Center on Pharmacogenomics, University of Miami Miller School of Medicine, Miami, Florida 33136-1013, USA. lribeiro@med.miami.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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