Linked Life Data

1763227

Source:http://linkedlifedata.com/resource/pubmed/id/1763227

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1992-2-7
pubmed:abstractText
We investigated the effect of CDP-choline on brain protection during extra-corporeal circulation (ECC) in patients submitted to open-heart surgery. We studied forty patients, using neurological, neuropsychological, neuroradiological (CT scan), and CBF evaluations. All the patients were evaluated two weeks before (T1), two weeks (T2), one month (T3) and six months after surgery (T4). Patients were randomly divided into two groups: subjects of the first group were treated with 2000 mg/die e.v. from two weeks before surgery to ten days after surgery, and then with 1000 mg/die i.m., 15 days per month, for the following 6 months (Group A), while subjects of the second group were treated with 100 mg/die, from two weeks before surgery to six months after surgery (Group B). After surgery, neither neurological symptoms nor morphostructural lesions were observed in the two groups. However, in the Group A, 75% (15 out of 20) of the patients evidenced reduced performances on neuropsychological tests at T2, compared to T1. At T4 only 66% (10 out of 15) of the impaired patients showed a persistence of the deficit. In the Group B 70% (14 out of 20) of the patients displayed reduced performances at T2. At T4, almost all of the patients, namely 86% (12 out of 14), showed a persistence of neuropsychological deficits. CBF data showed hypoperfusion areas in 9 patients in Group A (1.7 +/- 4.15 mean areas per patient), and in 10 patients in Group B (3.33 +/- 1.3 mean areas per patient), at T2. In 2.2+ off
pubmed:language
ita
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0034-1193
pubmed:author
pubmed:issnType
Print
pubmed:volume
82
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
573-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
[Brain protection in heart surgery].
pubmed:affiliation
Dipartimento di Scienze neurologiche, Università La Sapienza, Roma.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, English Abstract, Randomized Controlled Trial