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pubmed-article:17631145pubmed:abstractTextReduced p27(kip1) expression is a marker of poor prognosis in colorectal neoplasia, and inactivation of p27 in mice (p27(Delta51/Delta51)) causes increased intestinal epithelial cell proliferation and small and large intestinal neoplasia in a diet-dependent manner. Here, we addressed the role of p27 in untransformed intestinal epithelial cells in vivo and the consequence of its targeted inactivation.lld:pubmed
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pubmed-article:17631145pubmed:articleTitlep27kip1 Regulates cdk2 activity in the proliferating zone of the mouse intestinal epithelium: potential role in neoplasia.lld:pubmed
pubmed-article:17631145pubmed:affiliationDepartment of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom. pahjms@bris.ac.uklld:pubmed
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