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rdf:type |
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lifeskim:mentions |
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0027651,
umls-concept:C0035647,
umls-concept:C0035820,
umls-concept:C0169665,
umls-concept:C0226890,
umls-concept:C0441655,
umls-concept:C1332733,
umls-concept:C1332737,
umls-concept:C1514485,
umls-concept:C1705523,
umls-concept:C1710706
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pubmed:issue |
1
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pubmed:dateCreated |
2007-7-16
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pubmed:abstractText |
Reduced p27(kip1) expression is a marker of poor prognosis in colorectal neoplasia, and inactivation of p27 in mice (p27(Delta51/Delta51)) causes increased intestinal epithelial cell proliferation and small and large intestinal neoplasia in a diet-dependent manner. Here, we addressed the role of p27 in untransformed intestinal epithelial cells in vivo and the consequence of its targeted inactivation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cdk2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cdkn1a protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin D,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin E,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase 4,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclins
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0016-5085
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pubmed:author |
pubmed-author:AugenlichtLeonard HLH,
pubmed-author:BancroftLauraL,
pubmed-author:GuilmeauSandraS,
pubmed-author:KoffAndrewA,
pubmed-author:MariadasonJohn MJM,
pubmed-author:NasserShannon VSV,
pubmed-author:NicholasCourtneyC,
pubmed-author:SimpsonSharon ASA,
pubmed-author:SmarttHelena J MHJ,
pubmed-author:YangWancaiW,
pubmed-author:YehNancyN
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pubmed:issnType |
Print
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pubmed:volume |
133
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
232-43
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17631145-Animals,
pubmed-meshheading:17631145-Cell Division,
pubmed-meshheading:17631145-Cell Line, Tumor,
pubmed-meshheading:17631145-Colonic Neoplasms,
pubmed-meshheading:17631145-Cyclin D,
pubmed-meshheading:17631145-Cyclin E,
pubmed-meshheading:17631145-Cyclin-Dependent Kinase 2,
pubmed-meshheading:17631145-Cyclin-Dependent Kinase 4,
pubmed-meshheading:17631145-Cyclin-Dependent Kinase Inhibitor p21,
pubmed-meshheading:17631145-Cyclin-Dependent Kinase Inhibitor p27,
pubmed-meshheading:17631145-Cyclins,
pubmed-meshheading:17631145-Female,
pubmed-meshheading:17631145-G1 Phase,
pubmed-meshheading:17631145-Genotype,
pubmed-meshheading:17631145-Homeostasis,
pubmed-meshheading:17631145-Humans,
pubmed-meshheading:17631145-Intestinal Mucosa,
pubmed-meshheading:17631145-Male,
pubmed-meshheading:17631145-Mice,
pubmed-meshheading:17631145-Mice, Mutant Strains,
pubmed-meshheading:17631145-S Phase
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pubmed:year |
2007
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pubmed:articleTitle |
p27kip1 Regulates cdk2 activity in the proliferating zone of the mouse intestinal epithelium: potential role in neoplasia.
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pubmed:affiliation |
Department of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom. pahjms@bris.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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