Linked Life Data

17631144

Source:http://linkedlifedata.com/resource/pubmed/id/17631144

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-7-16
pubmed:abstractText
Aberrant activation of Ras and Raf in mitogen-activated protein kinase (MAPK) signaling has been linked with cancer. However, the role of MAPK kinases (MAPKKs or MEKs) in cancer is unclear, although constitutively activated MEK1, which does not exist in nature, is "oncogenic." Herein, we found that T-cell-originated protein kinase (TOPK), a member of the MAPKK protein family, is highly expressed in human colorectal cancer tissues and cell lines and plays an important role in the transformation of colorectal cancer.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0016-5085
pubmed:author
pubmed:issnType
Print
pubmed:volume
133
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
219-31
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:17631144-Amino Acid Sequence, pubmed-meshheading:17631144-Animals, pubmed-meshheading:17631144-Cell Transformation, Neoplastic, pubmed-meshheading:17631144-Colonic Neoplasms, pubmed-meshheading:17631144-Enzyme Activation, pubmed-meshheading:17631144-Epidermis, pubmed-meshheading:17631144-Feedback, Physiological, pubmed-meshheading:17631144-Gene Expression Regulation, Enzymologic, pubmed-meshheading:17631144-Gene Expression Regulation, Neoplastic, pubmed-meshheading:17631144-HCT116 Cells, pubmed-meshheading:17631144-Humans, pubmed-meshheading:17631144-MAP Kinase Signaling System, pubmed-meshheading:17631144-Mice, pubmed-meshheading:17631144-Mice, Inbred BALB C, pubmed-meshheading:17631144-Mice, Nude, pubmed-meshheading:17631144-Mitogen-Activated Protein Kinase 1, pubmed-meshheading:17631144-Molecular Sequence Data, pubmed-meshheading:17631144-Phosphorylation, pubmed-meshheading:17631144-Protein-Serine-Threonine Kinases
pubmed:year
2007
pubmed:articleTitle
Bidirectional signals transduced by TOPK-ERK interaction increase tumorigenesis of HCT116 colorectal cancer cells.
pubmed:affiliation
Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural