Linked Life Data

17629411

Source:http://linkedlifedata.com/resource/pubmed/id/17629411

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-8-13
pubmed:abstractText
OFF-center retinal ganglion cells (RGCs) occupy a smaller proportion than ON RGCs when RGCs regenerate axons into a transplanted peripheral nerve. We examined whether the regeneration ability of OFF RGCs in adult cats was promoted when the numbers of regenerating RGCs were increased with brain-derived neurotrophic factor (BDNF)+ciliary neurotrophic factor (CNTF)+forskolin (BCF) or 3,4-dihydro-8-(2-hydroxy-3-isopropylamino)-propoxy-3-nitroxy-2H-1-benzopyran (nipradilol), an anti-glaucoma drug. ON or OFF RGCs were morphologically determined on the basis of their dendritic ramification in the inner plexiform layer using computational analysis. In the normal intact retina the ratio of ON and OFF RGCs (ON/OFF ratio) was 1.25 (55%/44%); whereas, it was 2.61 in regenerating RGCs with saline injection (control) 6 weeks after peripheral nerve transplantation. Estimated numbers of regenerating ON and OFF RGCs were 2149 and 895, respectively. An injection of BCF increased only numbers of ON RGCs into 5766 (2.7-fold to control) but not that of OFF RGCs, n=858. Nipradilol increased both estimated numbers of ON (11,518, 5.4-fold to control) and OFF RGCs (7330, 8.2-fold to control). In the retinas with optic nerve (OpN) transection and intravitreal saline-, BCF- or nipradilol-injection, numbers of ON and OFF RGCs surviving axotomy showed similar trend to that in regenerating RGCs. Thus, nipradilol promoted the survival and regeneration abilities of both of ON and OFF RGCs whereas BCF only did the abilities of ON RGCs. The distribution of tropo-myosin-related kinase B, BDNF receptor, was sparser in the outer two thirds of inner plexiform layer. The lower surviving ability of OFF-RGCs may be attributed in part to the distribution.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0306-4522
pubmed:author
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
148
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
53-64
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:17629411-Age Factors, pubmed-meshheading:17629411-Animals, pubmed-meshheading:17629411-Antihypertensive Agents, pubmed-meshheading:17629411-Axons, pubmed-meshheading:17629411-Brain-Derived Neurotrophic Factor, pubmed-meshheading:17629411-Cats, pubmed-meshheading:17629411-Cell Count, pubmed-meshheading:17629411-Cell Shape, pubmed-meshheading:17629411-Cell Survival, pubmed-meshheading:17629411-Ciliary Neurotrophic Factor, pubmed-meshheading:17629411-Ciliary Neurotrophic Factor Receptor alpha Subunit, pubmed-meshheading:17629411-Dendrites, pubmed-meshheading:17629411-Denervation, pubmed-meshheading:17629411-Glaucoma, pubmed-meshheading:17629411-Graft Survival, pubmed-meshheading:17629411-Nerve Regeneration, pubmed-meshheading:17629411-Optic Nerve Injuries, pubmed-meshheading:17629411-Propanolamines, pubmed-meshheading:17629411-Receptor, trkB, pubmed-meshheading:17629411-Recovery of Function, pubmed-meshheading:17629411-Retinal Ganglion Cells
pubmed:year
2007
pubmed:articleTitle
Survival and axonal regeneration of off-center retinal ganglion cells of adult cats are promoted with an anti-glaucoma drug, nipradilol, but not BDNF and CNTF.
pubmed:affiliation
Department of Ophthalmology, Nagoya University Graduate School of Medicine, Turuma-cho 65, Showaku, Nagoya, Aichi 466-8550, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't