Linked Life Data

17628401

Source:http://linkedlifedata.com/resource/pubmed/id/17628401

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-12-31
pubmed:abstractText
The clinical features of tako-tsubo cardiomyopathy or transient left apical ballooning syndrome (LABS) have been clearly described, but the mechanisms are still unknown. Our objective was to prospectively assess coronary microcirculation at the acute phase of LABS and after functional recovery, using Doppler transthoracic echocardiography-coronary flow reserve (CFR). Twelve consecutive patients (11 women, mean age 68 +/- 10 years) satisfying the criteria for LABS underwent Doppler transthoracic echocardiography-CFR in the distal part of the left anterior descending coronary artery, using intravenous adenosine infusion (0.14 mg/kg/min over 2 minutes) at the acute phase and 25 +/- 3 days later. CFR was calculated as the ratio of hyperemic to basal mean diastolic flow velocity. Wall-motion score (WMS) was calculated using the 16-segment model during the same echocardiographic examination (normal WMS = 16). Doppler transthoracic echocardiography-CFR increased between the two examinations from 2.2 +/- 0.4 at the acute phase to 2.9 +/- 0.3 (P < .01), whereas WMS decreased (from 31 +/- 6 at the acute phase to 16.5 +/- 0.8, delta WMS = -14.6 +/- 6, P < .01). All patients exhibited an increase of CFR between the two tests (delta CFR = 0.73 +/- 0.39, range: 0.3-1.6). A significant correlation was observed between delta CFR and delta WMS (r = -0.89, P < .01). In conclusion, serial noninvasive CFR measurements performed in LABS suggested transient microcirculatory impairment during the acute phase of the syndrome. The wall-motion improvement parallel to the dynamic improvement of the microcirculation suggests a role of coronary microcirculatory damage in the pathogenesis of acute and transient wall-motion abnormalities in LABS.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1097-6795
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
72-7
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
The coronary flow reserve is transiently impaired in tako-tsubo cardiomyopathy: a prospective study using serial Doppler transthoracic echocardiography.
pubmed:affiliation
Department of Cardiology and Intensive Care Unit, Compiègne Hospital, Compiègne, France. patrickmeimoun@free.fr
pubmed:publicationType
Journal Article, Comparative Study