Linked Life Data

17624749

Source:http://linkedlifedata.com/resource/pubmed/id/17624749

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2007-8-27
pubmed:abstractText
The observation that individuals living in malaria endemic areas fail to develop sterilizing immunity to malaria infection has led to the assumption that malaria-specific immune responses are sub-optimal. Recently, T cell receptor (TCR) transgenic mice specific for the sporozoite and blood stages of the malaria parasite have been developed. Studies using these models have found that, unexpectedly, T cell memory in malaria is not noticeably defective. However, if T cell memory is 'normal' why are people not better protected? We suggest this is because protective immunity and T cell memory do not always correlate; moreover, T cells alone may simply not be able to provide the type of antibody-mediated sterilizing immunity induced by traditional vaccines.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0952-7915
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
424-9
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
T cell memory in malaria.
pubmed:affiliation
Department of Molecular Microbiology and Immunology, Johns Hopkins Malaria Research Institute, Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD 21205, USA. fzavala@hsph.edu
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural