|
pubmed:abstractText |
Homodimerization of histatin-derived peptides generally led to improved bactericidal activity against Staphylococcus aureus in vitro. In vivo, monomers and dimers were equally active in killing bacteria in mice with a soft tissue infection. Altogether, these peptides are promising compounds for the development of novel therapeutics against infections with drug-resistant bacteria.
|
|
pubmed:affiliation |
Section Nuclear Medicine, Division of Radiology, Leiden University Medical Center, Room C4-R-77, Albinusdreef 2, 2333 ZA Leiden, The Netherlands. m.m.welling@lumc.nl
|
