Linked Life Data

17619196

Source:http://linkedlifedata.com/resource/pubmed/id/17619196

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2007-12-5
pubmed:abstractText
Impaired lung development afflicts a range of newborns cared for by paediatric surgeons. As a result the speciality has led in the development of surgical models that illustrate the biomechanical regulation of lung growth. Using transgenic mutants, biologists have similarly discovered much about the biochemical regulation of prenatal lung growth. Airway smooth muscle (ASM) and its prenatal contractility airway peristalsis (AP) represent a novel link between these areas: ASM progenitors produce an essential biochemical factor for lung morphogenesis, whilst calcium-driven biomechanical ASM activity appears to regulate the same. In this invited paper, I take the opportunity both to review our recent findings on lung growth and prenatal ASM, and also to discuss mechanisms by which ASM contractility can regulate growth. Finally, I will introduce some novel ideas for exploration: ASM contractility could help to schedule parturition (pulmonary parturition clock) and could even be a generic model for smooth muscle regulation of morphogenesis in similar organs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0179-0358
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
827-36
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Exploiting mechanical stimuli to rescue growth of the hypoplastic lung.
pubmed:affiliation
Academy of Medical Sciences Clinician Scientist/Consultant Paediatric Surgeon, Alder Hey Children's Hospital, The Division of Child Health, University of Liverpool, Liverpool L12 2AP, UK. . e.jesudason@liv.ac.uk
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't