Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2007-7-25
pubmed:abstractText
Hematopoietic cell transplantation and solid organ transplantation are definitive therapies for several otherwise fatal conditions. Post-transplant immune reactions are the major cause of morbidity after transplantation and limit the extended use of these critical therapies. Post-transplant immune complications include graft rejection by the host and injury to the host mediated by the graft. Dendritic cells (DCs), a population of professional antigen-presenting cells, are thought to be crucial in triggering primary immune responses against both the graft and the host. Here, we review studies on DC homeostasis and trafficking after transplantation, and examine the role of the host and graft DC in post-transplant immune responses. We also discuss the therapeutic implications of these studies.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1471-4906
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
353-9
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Dendritic cell homeostasis and trafficking in transplantation.
pubmed:affiliation
Department of Gene and Cell Medicine, Mount Sinai Medical School, 1425 Madison Avenue, New York, NY 10029, USA. Miriam.Merad@mssm.edu
pubmed:publicationType
Journal Article, Review