Linked Life Data

17618662

Source:http://linkedlifedata.com/resource/pubmed/id/17618662

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-8-13
pubmed:abstractText
The present study evaluated the consequences of perinatal Delta(9)-tetrahydrocannabinol (Delta(9)-THC) treatment (5 mg/kg/day by gavage), either alone or combined with ethanol (3% v/v as the only fluid available), on ethanol self-administration and alcohol-seeking behavior in rat adult offspring. Furthermore, the effect of the selective cannabinoid CB(1) receptor antagonist, SR-141716A, on ethanol self-administration and on reinstatement of ethanol-seeking behavior induced either by stress or conditioned drug-paired cues was evaluated in adult offspring of rats exposed to the same perinatal treatment. Lastly, microarray experiments were conducted to evaluate if perinatal treatment with Delta(9)-tetrahydrocannabinol, ethanol or their combination causes long-term changes in brain gene expression profile in rats. The results of microarray data analysis showed that 139, 112 and 170 genes were differentially expressed in the EtOH, Delta(9)-THC, or EtOH+Delta(9)-THC group, respectively. No differences in alcohol self-administration and alcohol seeking were observed between rat groups. Intraperitoneal (IP) administration of SR-141716A (0.3-3.0 mg/kg) significantly reduced lever pressing for ethanol and blocked conditioned reinstatement of alcohol seeking. At the same doses SR-141716A failed to block foot-shock stress-induced reinstatement of alcohol seeking. The results reveal that perinatal exposure to Delta(9)-THC ethanol or their combination results in evident changes in gene expression patterns. However, these treatments do not significantly affect vulnerability to ethanol abuse in adult offspring. On the other hand, the results obtained with SR-141716A emphasize that endocannabinoid mechanisms play a major role in ethanol self-administration, as well as in the reinstatement of ethanol-seeking behavior induced by conditioned cues, supporting the idea that cannabinoid CB(1) receptor antagonists may represent interesting agents for the pharmacotherapy of alcoholism.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0041-008X
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
223
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
73-85
pubmed:dateRevised
2007-10-17
pubmed:meshHeading
pubmed-meshheading:17618662-Administration, Oral, pubmed-meshheading:17618662-Animals, pubmed-meshheading:17618662-Animals, Newborn, pubmed-meshheading:17618662-Behavior, Animal, pubmed-meshheading:17618662-Central Nervous System Depressants, pubmed-meshheading:17618662-Choice Behavior, pubmed-meshheading:17618662-Conditioning, Operant, pubmed-meshheading:17618662-Drug Therapy, Combination, pubmed-meshheading:17618662-Ethanol, pubmed-meshheading:17618662-Female, pubmed-meshheading:17618662-Gene Expression Profiling, pubmed-meshheading:17618662-Oligonucleotide Array Sequence Analysis, pubmed-meshheading:17618662-Piperidines, pubmed-meshheading:17618662-Pregnancy, pubmed-meshheading:17618662-Psychotropic Drugs, pubmed-meshheading:17618662-Pyrazoles, pubmed-meshheading:17618662-Rats, pubmed-meshheading:17618662-Rats, Wistar, pubmed-meshheading:17618662-Receptor, Cannabinoid, CB1, pubmed-meshheading:17618662-Self Administration, pubmed-meshheading:17618662-Tetrahydrocannabinol
pubmed:year
2007
pubmed:articleTitle
Role of cannabinoidergic mechanisms in ethanol self-administration and ethanol seeking in rat adult offspring following perinatal exposure to Delta9-tetrahydrocannabinol.
pubmed:affiliation
Department of Experimental Medicine and Public Health, University of Camerino, Via Scalzino 3, 62032 Camerino, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't