Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2007-9-10
pubmed:abstractText
In a genome-wide scan for type 2 diabetes (T2DM) in African American (AA) families, ordered subsets analysis (OSA) provided evidence for linkage to chromosome 20p in a subset with later age at diagnosis (max LOD 2.57, P=0.008). The proprotein convertase subtilisin/kexin-type 2 (PCSK2) gene is within the LOD-1 interval of this linkage peak. Twenty-nine single nucleotide polymorphisms (SNPs) were genotyped across this gene in 380 unrelated AA individuals with T2DM and end-stage renal disease (T2DM-ESRD), 278 AA controls, 96 European Americans (EA) and 120 Yoruba Nigerian (YRI) controls. In addition, 22 ancestry-informative markers (AIMs) were genotyped in all AA subjects, 120 YRI, and 282 EA controls. ADMIXMAP was used to model the distributions of admixture and generate score tests of allelic and haplotypic association. Association with T2DM was observed among 4 SNPs: rs2021785 (admixture-adjusted Pa=0.00014), rs1609659 (Pa=0.028), rs4814597 (Pa=0.039) and rs2269023 (Pa=0.043). None of the PCSK2 SNPs were associated with age at T2DM diagnosis. A variant in the PCKS2 gene, rs2021785, appears to play a role in susceptibility to T2DM in this AA population.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17618154-10447516, http://linkedlifedata.com/resource/pubmed/commentcorrection/17618154-11136232, http://linkedlifedata.com/resource/pubmed/commentcorrection/17618154-11246470, http://linkedlifedata.com/resource/pubmed/commentcorrection/17618154-12817591, http://linkedlifedata.com/resource/pubmed/commentcorrection/17618154-1528899, http://linkedlifedata.com/resource/pubmed/commentcorrection/17618154-15297300, http://linkedlifedata.com/resource/pubmed/commentcorrection/17618154-1594602, http://linkedlifedata.com/resource/pubmed/commentcorrection/17618154-16140553, http://linkedlifedata.com/resource/pubmed/commentcorrection/17618154-16244653, http://linkedlifedata.com/resource/pubmed/commentcorrection/17618154-16306388, http://linkedlifedata.com/resource/pubmed/commentcorrection/17618154-7663508, http://linkedlifedata.com/resource/pubmed/commentcorrection/17618154-7829629, http://linkedlifedata.com/resource/pubmed/commentcorrection/17618154-9192619, http://linkedlifedata.com/resource/pubmed/commentcorrection/17618154-9207799
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1096-7192
pubmed:author
pubmed:issnType
Print
pubmed:volume
92
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
145-50
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:articleTitle
Association of the proprotein convertase subtilisin/kexin-type 2 (PCSK2) gene with type 2 diabetes in an African American population.
pubmed:affiliation
Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural