Source:http://linkedlifedata.com/resource/pubmed/id/17616937
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
2007-7-9
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| pubmed:abstractText |
Heat shock proteins (HSPs) play an important role in the cellular response to environmental stress and exert a cytoprotective effect. Especially HSP70 is an effective inhibitor of apoptosis, suggesting a role of HSP70 in carcinogenesis and tumor progression. To explore the relevance of HSP70 in renal cell carcinomas (RCCs), we analyzed nuclear and cytoplasmic HSP70 protein expression in formalin-fixed tissue from 145 clear cell RCCs by immunohistochemistry as well as Western blot analysis. Nuclear HSP70 expression was found in all RCCs and 75% of the tumors also exhibited a cytoplasmic HSP70 staining. Importantly, RCCs showed significantly reduced cytoplasmic (p=0.001) and combined nuclear/cytoplasmic (p=0.0022) HSP70 expression when compared with their cells of origin. A significant (p=0.0176) decrease of nuclear HSP70 expression became evident from well to poorly differentiated clear cell RCCs. Quite similarly, a trend (p=0.0558) for reduced combined nuclear/cytoplasmic HSP70 expression was shown from early (pT1) to advanced (pT3) tumor stages. Nevertheless, no correlation between HSP70 expression and patients survival became evident. In conclusion, our investigation demonstrates a significant decrease of antiapoptotic HSP70 protein expression during carcinogenesis and during progression from well (G1) to poorly (G3) differentiated clear cell RCCs. Our results suggest that HSP70-mediated inhibition of apoptosis seems to be of minor importance for carcinogenesis and tumor progression in RCCs.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
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| pubmed:issn |
1699-5848
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
22
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1099-107
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| pubmed:meshHeading |
pubmed-meshheading:17616937-Adult,
pubmed-meshheading:17616937-Aged,
pubmed-meshheading:17616937-Aged, 80 and over,
pubmed-meshheading:17616937-Blotting, Western,
pubmed-meshheading:17616937-Carcinoma, Renal Cell,
pubmed-meshheading:17616937-Cell Count,
pubmed-meshheading:17616937-Cell Nucleus,
pubmed-meshheading:17616937-Cytoplasm,
pubmed-meshheading:17616937-Disease Progression,
pubmed-meshheading:17616937-Female,
pubmed-meshheading:17616937-Germany,
pubmed-meshheading:17616937-HSP70 Heat-Shock Proteins,
pubmed-meshheading:17616937-Humans,
pubmed-meshheading:17616937-Immunoenzyme Techniques,
pubmed-meshheading:17616937-Kidney Neoplasms,
pubmed-meshheading:17616937-Male,
pubmed-meshheading:17616937-Middle Aged,
pubmed-meshheading:17616937-Prognosis,
pubmed-meshheading:17616937-Retrospective Studies,
pubmed-meshheading:17616937-Survival Rate,
pubmed-meshheading:17616937-Tumor Markers, Biological
|
| pubmed:year |
2007
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| pubmed:articleTitle |
Expression of heat shock protein 70 in renal cell carcinoma and its relation to tumor progression and prognosis.
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| pubmed:affiliation |
Institute of Pathology, Heinrich-Heine University Hospital, Duesseldorf, Germany. Ramp@med.uni-duesseldorf.de
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| pubmed:publicationType |
Journal Article
|