|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0006118,
umls-concept:C0017638,
umls-concept:C0024432,
umls-concept:C0024485,
umls-concept:C0026336,
umls-concept:C0026473,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0205228,
umls-concept:C0546881,
umls-concept:C0599894,
umls-concept:C1515655
|
|
pubmed:dateCreated |
2007-8-20
|
|
pubmed:abstractText |
This study has shown that murine monocytes/macrophages (Mo/Ma) can be labeled simply and efficiently with large, green-fluorescent, micrometer-sized particles of iron-oxide (MPIO). Neither size nor proliferation rate of the Mo/Ma is significantly affected by this labeling. The labeled Mo/Ma have been administered intravenously to rats that had developed a glioma following stereotactic injection of C6 cells. The labeled Mo/Ma were shown to target the brain tumors, a process that could be monitored non-invasively using T2*-weighted MRI. MRI observations were confirmed by Prussian blue staining, lectin staining and fluorescence histology. Overall, the results of this study suggest that the use of Mo/Ma may be envisaged in the clinic for vectorizing therapeutic agents towards gliomas.
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1053-8119
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
37 Suppl 1
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
S47-58
|
|
pubmed:dateRevised |
2008-5-1
|
|
pubmed:meshHeading |
pubmed-meshheading:17611126-Animals,
pubmed-meshheading:17611126-Brain Neoplasms,
pubmed-meshheading:17611126-Cell Line, Tumor,
pubmed-meshheading:17611126-Cell Proliferation,
pubmed-meshheading:17611126-Coloring Agents,
pubmed-meshheading:17611126-Data Interpretation, Statistical,
pubmed-meshheading:17611126-Ferric Compounds,
pubmed-meshheading:17611126-Ferrocyanides,
pubmed-meshheading:17611126-Glioma,
pubmed-meshheading:17611126-Green Fluorescent Proteins,
pubmed-meshheading:17611126-Immunohistochemistry,
pubmed-meshheading:17611126-Iron,
pubmed-meshheading:17611126-Lectins,
pubmed-meshheading:17611126-Leukemia P388,
pubmed-meshheading:17611126-Macrophages,
pubmed-meshheading:17611126-Magnetic Resonance Imaging,
pubmed-meshheading:17611126-Monocytes,
pubmed-meshheading:17611126-Particle Size,
pubmed-meshheading:17611126-Rats,
pubmed-meshheading:17611126-Stereotaxic Techniques
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
In vivo MRI tracking of exogenous monocytes/macrophages targeting brain tumors in a rat model of glioma.
|
|
pubmed:affiliation |
Inserm, U836, Grenoble, F-38043, France; Université Joseph Fourier, Grenoble Institut des Neurosciences, Grenoble, F-38043, France.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
