Source:http://linkedlifedata.com/resource/pubmed/id/17610536
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2007-8-9
|
| pubmed:abstractText |
Magnetic resonance imaging (MRI) was used to quantify myocardial iron loading by T2* in 11 transfusion-dependent good prognostic myelodysplastic syndrome (MDS) patients. Myocardial T2*, left ventricular function and hepatic T2* were measured simultaneously. Patients had been on transfusion therapy for 13-123 months and had serum ferritin levels of 1109-6148 microg/l at the time of study. Five patients had not commenced iron chelation and had been transfused with a median of 63 red cell units and had a median serum ferritin level of 1490 microg/l. Six patients were on iron chelation and had been transfused with a median of 112 red cell units and had a median serum ferritin level of 4809 mug/l. Hepatic iron overload was mild in two, moderate in seven and severe in two patients. The median liver iron concentration was 5.9 mg/g dry weight in chelated patients and 9.5 mg/g in non-chelated patients (P = 0.17; not significant). Myocardial T2* indicated absent iron loading in 10/11 patients (91%; 95% confidence interval 62-98%) and borderline-normal in one patient. Left ventricular function was normal in all patients. No correlation was observed between increasing serum ferritin levels, hepatic iron overload and myocardial T2*. A long latent period relative to hepatic iron loading appears to predate the development of myocardial iron loading in transfusion-dependent MDS patients.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0007-1048
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
138
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
587-93
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| pubmed:dateRevised |
2008-5-2
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| pubmed:meshHeading |
pubmed-meshheading:17610536-Aged,
pubmed-meshheading:17610536-Aged, 80 and over,
pubmed-meshheading:17610536-Blood Transfusion,
pubmed-meshheading:17610536-Female,
pubmed-meshheading:17610536-Ferritins,
pubmed-meshheading:17610536-Follow-Up Studies,
pubmed-meshheading:17610536-Humans,
pubmed-meshheading:17610536-Iron,
pubmed-meshheading:17610536-Iron Chelating Agents,
pubmed-meshheading:17610536-Iron Overload,
pubmed-meshheading:17610536-Liver,
pubmed-meshheading:17610536-Magnetic Resonance Imaging,
pubmed-meshheading:17610536-Male,
pubmed-meshheading:17610536-Middle Aged,
pubmed-meshheading:17610536-Myelodysplastic Syndromes,
pubmed-meshheading:17610536-Myocardium,
pubmed-meshheading:17610536-Prognosis,
pubmed-meshheading:17610536-Prospective Studies
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
Myocardial iron loading by magnetic resonance imaging T2* in good prognostic myelodysplastic syndrome patients on long-term blood transfusions.
|
| pubmed:affiliation |
Department of Haematology, Royal Bournemouth Hospital, Bournemouth, UK.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|