Source:http://linkedlifedata.com/resource/pubmed/id/17608961
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2008-2-12
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| pubmed:abstractText |
Dissociation is a failure of perceptual, memorial and emotional integration that is associated with a variety of psychiatric disorders. Dissociative processes are usually attributed to the sequelae of childhood trauma although there are data to suggest that genetic influences are also important. Bipolar disorder (BD), a condition with a strong genetic basis, has also been associated with early psychological trauma. Since childhood trauma is a risk factor for both BD and dissociation, we tested for potential gene-childhood abuse interactions on dissociation in a pilot sample of BD probands and their affected and unaffected relatives (n=178). Dissociation was measured with the Dissociative Experiences Scale (DES II) and childhood maltreatment with the Childhood Trauma Questionnaire (CTQ). The BD and recurrent unipolar depression (MDE-R) groups showed higher levels of self-reported abuse and dissociation than their unaffected relatives. The low-activity Met allele of the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene was associated with lower levels of self-reported dissociation. Further, the functional catechol-O-methyltransferase (COMT) Val158Met polymorphism interacted significantly with total CTQ abuse scores to impact perceived dissociation. The Val/Val genotype was associated with increasing levels of dissociation in participants exposed to higher levels of childhood trauma. The opposite was observed in people with Met/Met genotypes who displayed decreased dissociation with increasing self-reported childhood trauma. The current findings support the involvement of the COMT Val158Met polymorphism in mediating the relationship between trauma and psychopathology.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
1461-1457
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
11
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
149-61
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| pubmed:meshHeading |
pubmed-meshheading:17608961-Adult,
pubmed-meshheading:17608961-Brain-Derived Neurotrophic Factor,
pubmed-meshheading:17608961-Catechol O-Methyltransferase,
pubmed-meshheading:17608961-Child,
pubmed-meshheading:17608961-Child Abuse,
pubmed-meshheading:17608961-Dissociative Disorders,
pubmed-meshheading:17608961-Female,
pubmed-meshheading:17608961-Gene Frequency,
pubmed-meshheading:17608961-Genetic Predisposition to Disease,
pubmed-meshheading:17608961-Humans,
pubmed-meshheading:17608961-Male,
pubmed-meshheading:17608961-Middle Aged,
pubmed-meshheading:17608961-Phenotype,
pubmed-meshheading:17608961-Pilot Projects,
pubmed-meshheading:17608961-Polymorphism, Genetic,
pubmed-meshheading:17608961-Psychometrics,
pubmed-meshheading:17608961-Questionnaires,
pubmed-meshheading:17608961-Risk Factors
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| pubmed:year |
2008
|
| pubmed:articleTitle |
The relationship between childhood abuse and dissociation. Is it influenced by catechol-O-methyltransferase (COMT) activity?
|
| pubmed:affiliation |
MRC/UCT Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa. savitzj@mail.nih.gov
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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