|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0010802,
umls-concept:C0023487,
umls-concept:C0026882,
umls-concept:C0030705,
umls-concept:C0040808,
umls-concept:C0052416,
umls-concept:C0175668,
umls-concept:C0205171,
umls-concept:C0332293,
umls-concept:C0392747,
umls-concept:C0450442,
umls-concept:C1274040,
umls-concept:C1333568,
umls-concept:C1518321
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
2007-7-3
|
|
pubmed:abstractText |
Ninety-eight newly diagnosed cases of PML-RARalpha positive APL were treated with a regimen of single agent ATO. FLT3 activating mutations were seen in 33% and an additional cytogenetic finding was noted in 23.2%. FLT3 activating mutations were significantly associated with a bcr3 PML-RARalpha isoform (p=0.012) and a delay in achieving a molecular remission (p=0.022). Neither FLT3 activating mutations nor secondary cytogenetic changes had an impact on clinical outcome.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
1592-8721
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
92
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
994-5
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:17606455-Arsenicals,
pubmed-meshheading:17606455-Cytogenetics,
pubmed-meshheading:17606455-Humans,
pubmed-meshheading:17606455-Leukemia, Promyelocytic, Acute,
pubmed-meshheading:17606455-Mutation,
pubmed-meshheading:17606455-Oxides,
pubmed-meshheading:17606455-Prognosis,
pubmed-meshheading:17606455-Retrospective Studies,
pubmed-meshheading:17606455-Treatment Outcome,
pubmed-meshheading:17606455-fms-Like Tyrosine Kinase 3
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Impact of FLT3 mutations and secondary cytogenetic changes on the outcome of patients with newly diagnosed acute promyelocytic leukemia treated with a single agent arsenic trioxide regimen.
|
|
pubmed:affiliation |
Department of Haematology, Christian Medical College, Vellore, 632004 India. vikram@cmcvellore.ac.in
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|
pubmed:publicationType |
Journal Article
|
