17606371

Source:http://linkedlifedata.com/resource/pubmed/id/17606371

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0243077, umls-concept:C0379528
pubmed:issue	16
pubmed:dateCreated	2007-7-30
pubmed:abstractText	A series of N-alkylbenzenesulfonamides were developed from a high throughput screening hit. Classic and parallel synthesis strategies were employed to produce compounds with good in vitro and in vivo gamma-secretase activity.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Amyloid Precursor Protein Secretases, http://linkedlifedata.com/resource/pubmed/chemical/Amyloid beta-Peptides, http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides
pubmed:status	MEDLINE
pubmed:month	Aug
pubmed:issn	0960-894X
pubmed:author	pubmed-author:BartenDonna MDM, pubmed-author:BergstromCarl PCP, pubmed-author:BronsonJoanne JJJ, pubmed-author:CorsaJason AJA, pubmed-author:DeshpandeMilind SMS, pubmed-author:FelsensteinKevin MKM, pubmed-author:GussValerie LVL, pubmed-author:HanselSteven BSB, pubmed-author:JohnsonGrahamG, pubmed-author:KeavyDaniel JDJ, pubmed-author:LauWai YWY, pubmed-author:MockJeremyJ, pubmed-author:ParkerMichael FMF, pubmed-author:PolsonCraig TCT, pubmed-author:PrasadC V CCV, pubmed-author:SloanCharles PCP, pubmed-author:SmithDavid WDW, pubmed-author:WallaceOwen BOB, pubmed-author:WangHenry HHH, pubmed-author:WilliamsAndrewA, pubmed-author:ZhengMingM
pubmed:issnType	Print
pubmed:day	15
pubmed:volume	17
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	4432-6
pubmed:dateRevised	2010-11-18
pubmed:meshHeading	pubmed-meshheading:17606371-Amyloid Precursor Protein Secretases, pubmed-meshheading:17606371-Amyloid beta-Peptides, pubmed-meshheading:17606371-Animals, pubmed-meshheading:17606371-Brain, pubmed-meshheading:17606371-Mice, pubmed-meshheading:17606371-Mice, Transgenic, pubmed-meshheading:17606371-Molecular Structure, pubmed-meshheading:17606371-Protein Binding, pubmed-meshheading:17606371-Sulfonamides
pubmed:year	2007
pubmed:articleTitle	N-(5-chloro-2-(hydroxymethyl)-N-alkyl-arylsulfonamides as gamma-secretase inhibitors.
pubmed:affiliation	Department of Discovery Chemistry, Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA. parkerm@BMS.com
pubmed:publicationType	Journal Article