Linked Life Data

17606290

Source:http://linkedlifedata.com/resource/pubmed/id/17606290

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5-6
pubmed:dateCreated
2007-7-10
pubmed:abstractText
Relationships between nutrition and longevity are of growing interest. Here we analysed the influences of dietary restriction on the survival of Drosophila exposed to atmospheric oxygen or to chronic hypoxia. Dietary restriction was achieved by food dilution, by sucrose restriction or by yeast restriction. Sucrose and yeast influenced survival in a complex manner that was best visualised using a phenotypic landscape metaphor. Survival contour maps integrate poorly understood behavioural adaptations, metabolic regulations and nutrient signalling pathways in a comprehensive manner. Dietary yeast produced a bell shaped survival response which was dependent on sucrose. Hypoxic flies had a reduced longevity as compared to normoxic flies and their dependence on specific nutrients was modified. Yeast which was beneficial to normoxic flies was toxic for hypoxic flies. In addition hypoxic flies were more resistant to starvation. We conclude that the survival and the hypoxic tolerance of Drosophila have different nutritional requirements.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0047-6374
pubmed:author
pubmed:issnType
Print
pubmed:volume
128
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
401-6
pubmed:meshHeading
pubmed:articleTitle
Diet dependent longevity and hypoxic tolerance of adult Drosophila melanogaster.
pubmed:affiliation
Inserm U615, Nice F-06108, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't