Linked Life Data

1760364

Source:http://linkedlifedata.com/resource/pubmed/id/1760364

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1992-2-13
pubmed:abstractText
Extensive animal data suggest that prostaglandins are involved in the epidermal induction of ornithine decarboxylase (ODC). We undertook this study to investigate their role during induction of hyperproliferation in human skin. Topical indomethacin (Elmetacin) or vehicle only were applied under occlusion on the backs of healthy volunteers. This was followed 1 h later by Sellotape stripping and biopsies were carried out for the estimation of the levels of ODC. There was no significant difference in the level of ODC in the indomethacin-treated and control sites. Also, test sites were irradiated with 3 MEDs of UVB, and this was immediately followed by the application of indomethacin or vehicle only on the irradiated sites. After 8 h biopsies were taken and the levels of ODC were again similar in both sites. The data indicate that the cyclo-oxygenase products in human epidermis do not contribute to the induction of ODC.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0007-0963
pubmed:author
pubmed:issnType
Print
pubmed:volume
125
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
577-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Cyclo-oxygenase products do not participate in the induction of ornithine decarboxylase in human epidermis.
pubmed:affiliation
Department of Dermatology, University of Nijmegen, The Netherlands.
pubmed:publicationType
Journal Article, Comparative Study