Linked Life Data

17603258

Source:http://linkedlifedata.com/resource/pubmed/id/17603258

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2007-7-2
pubmed:abstractText
The growing numerical gap between the number of patients and available human donor organs have led to a revival interest in xenotransplantation. This review will mainly focus on the clinical affairs of xenotransplantation and the project of producing the gene modified pigs. Trials, designed to overcome xenogenic rejection by the expression of human complement regulatory protein (CRP), such as DAF (CD55), on the pig organ and knocking out the alpha-Gal epitope(Galalpha1-3Galbeta1-4GlcNAc-R), which is biosynthesized by the action of alpha1,3 galactosyltransferase (alpha1,3GT), were accomplished in several institutes, such as Harvard University, Pittsburgh University, Mayo Clinic, and BresaGen. We have also produced the [DAF(CD55)+GnT-III+alpha-Gal KO] pigs in last year. On the other hand, the clinical pig islets transplantation was done in many countries, such as Russia, Sweden, Mexico and China, until 2005. In addition, the new clinical trials of pig islets transplantation will be started in USA within three years. In addition, as the current studies in the xenotransplantation field, the strategies for the downregulation of the glycoantigen, complement activation, NK cell, and other immuno responces on the xenografts, are reviewed. The studies for the infectivity of porcine endogenous retrovirus (PERV) to human cells are also introduced.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0911-4300
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
174-84
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
[Clinical xenotransplantation].
pubmed:affiliation
Division of Organ Transplantation, Department of Molecular therapeutics, Osaka University Graduate School of Medicine.
pubmed:publicationType
Journal Article, English Abstract, Review