Source:http://linkedlifedata.com/resource/pubmed/id/17603217
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2007-7-2
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| pubmed:abstractText |
It is well recognized that the theophylline (TP) concentration in human tears correlates well with the free TP concentration in human plasma. However this correlation was found only in a very narrow range of concentrations of TP, and pharmacokinetic analysis of TP in tears has not been carried out for a wide range of concentrations of TP. The aims of this investigation were to develop a simple kinetic model for TP in guinea pig plasma (total [Cf+b] and free [Cf]), cerebrospinal fluid (CSF) [C](CSF) and tears [C](T), and to examine whether [Cf], [Cf+b] and [C](CSF) can be predicted from [C](T) using the resulting kinetic parameters. [Cf+b], [Cf], [C](CSF) and [C](T) were determined by GC/EI-SIM following bolus i.v. injection of TP in doses of 10, 50 and 100 mg/kg into guinea pigs. The wide range of concentrations of [Cf+b] could be quantitatively described by a two-compartment model with non-linear elimination kinetics and individual volume distribution of TP at each dose. [C](T) and [C](CSF) were analyzed using passive diffusion models with and without the pH-partition theory, respectively. The value of [Cf] could be predicted from the value of [C](T). Thus, the measurement of [C](T) which can be collected non-invasively would be a useful method for the therapeutic drug monitoring of TP.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
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| pubmed:issn |
1347-4367
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
22
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
169-77
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| pubmed:meshHeading |
pubmed-meshheading:17603217-Algorithms,
pubmed-meshheading:17603217-Aminophylline,
pubmed-meshheading:17603217-Animals,
pubmed-meshheading:17603217-Guinea Pigs,
pubmed-meshheading:17603217-Injections, Intraventricular,
pubmed-meshheading:17603217-Least-Squares Analysis,
pubmed-meshheading:17603217-Male,
pubmed-meshheading:17603217-Models, Biological,
pubmed-meshheading:17603217-Tears,
pubmed-meshheading:17603217-Theophylline,
pubmed-meshheading:17603217-Time Factors,
pubmed-meshheading:17603217-Vasodilator Agents
|
| pubmed:year |
2007
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| pubmed:articleTitle |
Pharmacokinetics of theophylline in Guinea pig tears.
|
| pubmed:affiliation |
Department of Functional and Analytical Food Sciences, Faculty of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan. sato@nupals.ac.jp
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| pubmed:publicationType |
Journal Article
|