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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-7-2
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pubmed:abstractText |
Thyroid hormones act directly on gene transcription in the post-natal developing cerebellum, controlling neuronal, and glial cell differentiation. We have combined three experimental approaches to identify the target genes that are underlying this phenomenon: 1) a microarray analysis of gene expression to identify hormone responsive genes in the cerebellum of Pax8-/- mice, a transgenic mouse model of congenital hypothyroidism; 2) a similar microarray analysis on primary culture of cerebellum neurons; and 3) a bioinformatics screen of conserved putative-binding sites in the mouse genome. This identifies surprisingly a small set of target genes, which, for some of them, might be key regulators of cerebellum development and neuronal differentiation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1479-6813
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pubmed:author |
pubmed-author:AllioliNathalieN,
pubmed-author:CompeEmmanuelE,
pubmed-author:FlamantFrédéricF,
pubmed-author:Grijota-MartinezCarmenC,
pubmed-author:GuyotRomainR,
pubmed-author:LaperrièreDavidD,
pubmed-author:MaderSylvieS,
pubmed-author:MeltzerPaulP,
pubmed-author:QuignodonLaureL,
pubmed-author:SamarutJacquesJ,
pubmed-author:WalkerRobertR
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pubmed:issnType |
Electronic
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
17-28
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pubmed:meshHeading |
pubmed-meshheading:17601882-Aging,
pubmed-meshheading:17601882-Animals,
pubmed-meshheading:17601882-Animals, Newborn,
pubmed-meshheading:17601882-Cerebellum,
pubmed-meshheading:17601882-Gene Expression Regulation, Developmental,
pubmed-meshheading:17601882-Mice,
pubmed-meshheading:17601882-Mice, Inbred C57BL,
pubmed-meshheading:17601882-Mice, Inbred Strains,
pubmed-meshheading:17601882-Mice, Knockout,
pubmed-meshheading:17601882-Neurons,
pubmed-meshheading:17601882-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:17601882-Paired Box Transcription Factors,
pubmed-meshheading:17601882-RNA,
pubmed-meshheading:17601882-Receptors, Thyroid Hormone,
pubmed-meshheading:17601882-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17601882-Thyroxine,
pubmed-meshheading:17601882-Triiodothyronine
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pubmed:year |
2007
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pubmed:articleTitle |
A combined approach identifies a limited number of new thyroid hormone target genes in post-natal mouse cerebellum.
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pubmed:affiliation |
Institut de Génomique Fonctionnelle de Lyon, Ecole Normale Supérieure de Lyon, Université de Lyon, UMR INRA CNRS 5242, IFR128 46 allée d'Italie, 69364 Lyon Cedex 07, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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