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rdf:type |
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lifeskim:mentions |
umls-concept:C0001792,
umls-concept:C0006560,
umls-concept:C0021760,
umls-concept:C0025344,
umls-concept:C0041980,
umls-concept:C0337810,
umls-concept:C0392747,
umls-concept:C0439234,
umls-concept:C0443172,
umls-concept:C0681842,
umls-concept:C1561960,
umls-concept:C1948053,
umls-concept:C2347804
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pubmed:issue |
1
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pubmed:dateCreated |
2007-6-29
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pubmed:abstractText |
The role of uric acid (UA) in the process of atherothrombosis is controversial. Although serum UA has powerful antioxidant properties, epidemiological studies showed that UA was a risk factor for cardiovascular diseases and was positively associated with proinflammatory markers. Relations between baseline UA and changes in UA circulating levels with C-reactive protein (CRP) and interleukin-6 (IL-6) after 3 years of follow-up in a cohort of 892 Italian men and women aged 21 to 98 years was investigated. Subjects had complete baseline and follow-up data for UA, inflammatory markers, and covariates. An autoregressive approach was used to study such a relation. In adjusted analyses, baseline UA and changes in UA predicted a 3-year change in CRP (p = 0.028), but not IL-6 (p = 0.101). The relation between UA and CRP persisted after adjustment for baseline IL-6. Subjects with high UA at baseline had a progressively higher probability of developing clinically relevant increased IL-6 (>2.5 pg/ml) and CRP (>3 mg/L) during 3 years. In conclusion, our study suggests that in a population-based cohort, baseline UA and changes in circulating UA during 3 years of follow-up predict changes in circulating CRP independent of relevant confounders, including baseline IL-6.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17599452-10366160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17599452-10815083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17599452-10954008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17599452-11129752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17599452-11950622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17599452-12045167,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17599452-12105162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17599452-12485966,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17599452-12551878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17599452-12618270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17599452-12707250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17599452-12707287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17599452-12843346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17599452-12859163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17599452-12900431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17599452-12908717,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17599452-14520412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17599452-14962156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17599452-15179098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17599452-15277287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17599452-15921781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17599452-16084170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17599452-16611671,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17599452-16871533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17599452-7695456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17599452-7702038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17599452-7807497
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0002-9149
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
100
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
115-21
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:17599452-Adult,
pubmed-meshheading:17599452-Aged,
pubmed-meshheading:17599452-Aged, 80 and over,
pubmed-meshheading:17599452-Atherosclerosis,
pubmed-meshheading:17599452-C-Reactive Protein,
pubmed-meshheading:17599452-Cardiovascular Diseases,
pubmed-meshheading:17599452-Cohort Studies,
pubmed-meshheading:17599452-Female,
pubmed-meshheading:17599452-Follow-Up Studies,
pubmed-meshheading:17599452-Humans,
pubmed-meshheading:17599452-Interleukin-6,
pubmed-meshheading:17599452-Italy,
pubmed-meshheading:17599452-Male,
pubmed-meshheading:17599452-Middle Aged,
pubmed-meshheading:17599452-Predictive Value of Tests,
pubmed-meshheading:17599452-Thrombosis,
pubmed-meshheading:17599452-Time Factors,
pubmed-meshheading:17599452-Uric Acid
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pubmed:year |
2007
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pubmed:articleTitle |
Usefulness of uric acid to predict changes in C-reactive protein and interleukin-6 in 3-year period in Italians aged 21 to 98 years.
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pubmed:affiliation |
Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural,
Research Support, N.I.H., Intramural
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