Source:http://linkedlifedata.com/resource/pubmed/id/17597826
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
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| pubmed:dateCreated |
2007-10-15
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| pubmed:abstractText |
Genes involved in the inflammatory response resulting in allergic contact dermatitis (ACD) are only partly known. In this study, we introduce the use of high-density oligonucleotide arrays for gene expression profiling in human skin during the elicitation of ACD. Skin biopsies from normal and nickel-exposed skin were obtained from seven nickel-allergic patients and five nonallergic controls at four different time points during elicitation of eczema. Each gene expression profile was analyzed by hybridization to high-density oligonucleotide arrays. Cluster analysis of 74 genes found to be differentially expressed in the patients over time revealed that the patient samples may be categorized into two groups: an early time-point group (no clinical reaction) and a late time-point group (clinical reaction). Bioinformatics analyses unraveled the potential involvement of signal transducers and activator of transcription and small/mothers against decepentaplegic (SMAD) transcription factors in the late time-point gene expression patterns. Concerning specific genes, the homeostatic chemokine CCL19 was unexpectedly found to be highly expressed in cells scattered in the deep dermis of the late time-point samples. Taken together, these findings suggest hitherto unknown roles of SMAD transcription factors and of CCL19 in the elicitation phase of ACD.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CCL19 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL19,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CC,
http://linkedlifedata.com/resource/pubmed/chemical/Smad Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta
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| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
1523-1747
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
127
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
2585-95
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:17597826-Adult,
pubmed-meshheading:17597826-Biopsy,
pubmed-meshheading:17597826-Chemokine CCL19,
pubmed-meshheading:17597826-Chemokines, CC,
pubmed-meshheading:17597826-Cluster Analysis,
pubmed-meshheading:17597826-Dermatitis, Allergic Contact,
pubmed-meshheading:17597826-Down-Regulation,
pubmed-meshheading:17597826-Female,
pubmed-meshheading:17597826-Gene Expression Profiling,
pubmed-meshheading:17597826-Humans,
pubmed-meshheading:17597826-Middle Aged,
pubmed-meshheading:17597826-Multivariate Analysis,
pubmed-meshheading:17597826-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:17597826-Skin,
pubmed-meshheading:17597826-Smad Proteins,
pubmed-meshheading:17597826-Transcription Factors,
pubmed-meshheading:17597826-Transforming Growth Factor beta,
pubmed-meshheading:17597826-Up-Regulation
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| pubmed:year |
2007
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| pubmed:articleTitle |
Gene expression time course in the human skin during elicitation of allergic contact dermatitis.
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| pubmed:affiliation |
The National Allergy Research Centre for Consumer Products, Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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