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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2007-7-30
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pubmed:abstractText |
On the borders of Thailand, Plasmodium falciparum has become resistant to nearly all available drugs, and there is an urgent need to find new antimalarial drugs or drug combinations. Ferroquine (SSR97193) is a new 4-aminoquinoline antimalarial active against chloroquine resistant and sensitive P. falciparum strains in vivo and in vitro. This antimalarial organic iron complex (a ferrocenyl group has been associated with chloroquine) is meant to use the affinity of Plasmodium for iron to increase the probability for encountering the anti-malarial molecule.The aim of the present study was to investigate the activity of ferroquine against P. falciparum isolates from an area with a known high multi-drug resistance rate.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17597537-10365399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17597537-11132385,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17597537-11293573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17597537-11463109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17597537-11481286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17597537-11903989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17597537-12654770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17597537-1493976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17597537-15047560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17597537-15228723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17597537-15878154,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17597537-15934779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17597537-16464254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17597537-16575722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17597537-6118522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17597537-9371235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17597537-9517929,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17597537-9586944
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1475-2875
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
81
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17597537-Aminoquinolines,
pubmed-meshheading:17597537-Animals,
pubmed-meshheading:17597537-Antimalarials,
pubmed-meshheading:17597537-Dose-Response Relationship, Drug,
pubmed-meshheading:17597537-Ferrous Compounds,
pubmed-meshheading:17597537-Humans,
pubmed-meshheading:17597537-Malaria, Falciparum,
pubmed-meshheading:17597537-Myanmar,
pubmed-meshheading:17597537-Parasitic Sensitivity Tests,
pubmed-meshheading:17597537-Plasmodium falciparum,
pubmed-meshheading:17597537-Thailand
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pubmed:year |
2007
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pubmed:articleTitle |
In vitro activity of ferroquine (SSR 97193) against Plasmodium falciparum isolates from the Thai-Burmese border.
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pubmed:affiliation |
Shoklo Malaria Research Unit, Mae Sot, Tak, Thailand. marion@shoklo-unit.com <marion@shoklo-unit.com>
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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