Linked Life Data

17597225

Source:http://linkedlifedata.com/resource/pubmed/id/17597225

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2007-7-9
pubmed:abstractText
Valid localization is a prerequisite to study plasticity of the somatosensory cortex in humans. We compared the localizations of left and right thumb and little finger in the primary somatosensory cortex obtained with fMRI and MEG. Representations were investigated in 11 healthy right-handed subjects using echoplanar fMRI and 122-channel MEG together with electric finger stimulation. Activation observed with fMRI was based on an increase in the BOLD signal. Most of the activation clusters (71.1%) were located on the lateral surface of the postcentral gyrus. Representations of thumb and little finger were 17mm apart on average and consistently showed a somatotopic arrangement with the thumb representation inferior, lateral, and anterior to the representation of the little finger. Activation observed with MEG was modelled by equivalent current dipoles. Dipole localization was compatible with an assumed origin of activation within the posterior wall of the central sulcus. The Euclidian distance between corresponding dipoles was 11.5mm on average with deviations from the expected spatial arrangement of 35, 30, and 20% in the x-, y- und z-direction, respectively. Our study demonstrates how relative localization of somatosensory activations can serve as an indicator for localization validity when comparing different methods or studying somatosensory plasticity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0165-0270
pubmed:author
pubmed:issnType
Print
pubmed:day
30
pubmed:volume
164
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
280-91
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Studying the human somatosensory hand area: A new way to compare fMRI and MEG.
pubmed:affiliation
Department of Neurology, University Hospital Düsseldorf, Moorenstr. 5, 40225 Düsseldorf, Germany. cornelia@fmrib.ox.ac.uk
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't