|
rdf:type |
|
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lifeskim:mentions |
umls-concept:C0021308,
umls-concept:C0025663,
umls-concept:C0038128,
umls-concept:C0077258,
umls-concept:C0184511,
umls-concept:C0205155,
umls-concept:C0205554,
umls-concept:C0449468,
umls-concept:C1522472,
umls-concept:C1551341,
umls-concept:C1552858,
umls-concept:C1552923,
umls-concept:C1552924,
umls-concept:C1705191,
umls-concept:C1882598
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pubmed:issue |
3
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|
pubmed:dateCreated |
2007-10-15
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|
pubmed:abstractText |
The identification of acute neuroprotectants relies heavily on rodent stroke models. It is well know that some of the more common models used can exhibit a relatively high degree of inter animal variability. This necessitates the need to increase the sample size per group and to run concomitant positive and negative control groups with each study in order to increase the consistency and reproducibility of the model. As such, one aspect of these studies that has become more labor intensive is the measurement of infarct volume post study.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
|
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:issn |
1056-8719
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
339-43
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pubmed:meshHeading |
pubmed-meshheading:17596972-Animals,
pubmed-meshheading:17596972-Brain,
pubmed-meshheading:17596972-Brain Chemistry,
pubmed-meshheading:17596972-Brain Infarction,
pubmed-meshheading:17596972-Dizocilpine Maleate,
pubmed-meshheading:17596972-Image Processing, Computer-Assisted,
pubmed-meshheading:17596972-Injections, Intraperitoneal,
pubmed-meshheading:17596972-Neuroprotective Agents,
pubmed-meshheading:17596972-Rats,
pubmed-meshheading:17596972-Reproducibility of Results,
pubmed-meshheading:17596972-Staining and Labeling,
pubmed-meshheading:17596972-Tetrazolium Salts,
pubmed-meshheading:17596972-Time Factors
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pubmed:articleTitle |
An improved automated method to quantitate infarct volume in triphenyltetrazolium stained rat brain sections.
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pubmed:affiliation |
Department of Stroke and Neurodegeneration, Merck Research Laboratories, West Point, PA 19486, USA.
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pubmed:publicationType |
Journal Article
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