Linked Life Data

17596702

Source:http://linkedlifedata.com/resource/pubmed/id/17596702

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
2007-6-28
pubmed:abstractText
Curcumin-derived oxazoles and pyrazoles were synthesized in order to minimize the metal chelation properties of curcumin. The reduced rotational freedom and the absence of stereoisomers was anticipated to enhance the inhibition of gamma-secretase. Accordingly, the replacement of the 1,3-dicarbonyl moiety by isosteric heterocycles turned curcumin analogue oxazoles and pyrazoles into potent gamma-secretase inhibitors. Compounds 4a-i were found to be potent inhibitors of gamma-secretase and displayed activity in the low micromolar range.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1660-2854
pubmed:author
pubmed:copyrightInfo
2007 S. Karger AG, Basel
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
88-93
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Curcumin derivatives inhibit or modulate beta-amyloid precursor protein metabolism.
pubmed:affiliation
Clemens Schöpf-Institute of Chemistry and Biochemistry, Darmstadt University of Technology, Darmstadt, Germany.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't