|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
26
|
|
pubmed:dateCreated |
2007-6-28
|
|
pubmed:abstractText |
Neuronal circuits including medium spiny neurons (MSNs) in the nucleus accumbens (NAc) and melanin-concentrating hormone (MCH)-containing neurons in the lateral hypothalamic area (LHA) are hypothesized to play an important role in hedonic feeding. A reciprocal connection between NAc MSNs and MCH-containing neurons is proposed to form a neuronal circuit that is involved in hedonic feeding. Although NAc MSNs have been shown to receive projection from MCH-containing neurons, it is not known whether MCH-containing neurons in the LHA also receive direct inputs from NAc MSNs. Here, we developed a genetic approach that allows us to visualize almost all striatal MSNs including NAc MSNs. We demonstrate that striatal MSNs terminate in a distinct region within the anterior LHA, and that the terminal area of striatal MSNs in this region contains glutamatergic neurons and is distinctly separate from orexin/hypocretin- or MCH-containing neurons. These observations suggest that NAc MSNs do not directly innervate MCH-containing neurons, but may indirectly signal MCH-containing neurons via glutamatergic neurons in the anterior LHA.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
1529-2401
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
27
|
|
pubmed:volume |
27
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
6948-55
|
|
pubmed:meshHeading |
pubmed-meshheading:17596443-Animals,
pubmed-meshheading:17596443-Corpus Striatum,
pubmed-meshheading:17596443-Feeding Behavior,
pubmed-meshheading:17596443-Green Fluorescent Proteins,
pubmed-meshheading:17596443-Hypothalamic Area, Lateral,
pubmed-meshheading:17596443-Hypothalamic Hormones,
pubmed-meshheading:17596443-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:17596443-Melanins,
pubmed-meshheading:17596443-Mice,
pubmed-meshheading:17596443-Mice, Transgenic,
pubmed-meshheading:17596443-Neural Inhibition,
pubmed-meshheading:17596443-Neural Pathways,
pubmed-meshheading:17596443-Neurons,
pubmed-meshheading:17596443-Neuropeptides,
pubmed-meshheading:17596443-Pituitary Hormones,
pubmed-meshheading:17596443-Presynaptic Terminals,
pubmed-meshheading:17596443-Reward,
pubmed-meshheading:17596443-Synaptic Transmission,
pubmed-meshheading:17596443-gamma-Aminobutyric Acid
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Striatal medium spiny neurons terminate in a distinct region in the lateral hypothalamic area and do not directly innervate orexin/hypocretin- or melanin-concentrating hormone-containing neurons.
|
|
pubmed:affiliation |
Molecular Neurogenetics Unit, Horizontal Medical Research Organization, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
