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pubmed-article:17595049pubmed:abstractTextPlasmid DNA vectors offer the potential of safe gene therapy avoiding viral vector-mediated toxicity and immunogenicity. As plasmid DNA is bacterial in origin, presence of bacterial lipopolysaccharide (LPS) or unmethylated CpG dinucleotides may stimulate host innate immunity.lld:pubmed
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pubmed-article:17595049pubmed:copyrightInfoCopyright 2007 John Wiley & Sons, Ltd.lld:pubmed
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pubmed-article:17595049pubmed:articleTitleIn vitro and in vivo evaluation of intrinsic immunogenicity of reporter and insulin gene therapy plasmids.lld:pubmed
pubmed-article:17595049pubmed:affiliationDiabetes Research Group, Institute of Cell and Molecular Biosciences, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.lld:pubmed
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