Linked Life Data

17594338

Source:http://linkedlifedata.com/resource/pubmed/id/17594338

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2007-6-27
pubmed:abstractText
Antibody-mediated inflammation is believed to contribute to tissue injury in multiple sclerosis (MS). The majority of patients with MS have oligoclonal bands (OCB), corresponding to antibodies against a variety of antigens, in their cerebrospinal fluid (CSF). The relation of CSF OCB and disease progression in MS is uncertain. To investigate whether there is a relation between CSF OCB and a more aggressive disease course of MS, 143 patients with definite MS according to the Poser diagnostic criteria and CSF analysis at time of diagnosis were followed over a period of 5 years. There were no differences in presence or number of CSF OCB between patients with significant worsening of disability and stable patients. There were no differences in presence or number of CSF OCB between patients with stable relapsing-remitting MS and patients developing secondary progression during follow-up. The presence or number of CSF OCB does not seem to influence early disease progression in MS.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1468-1331
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
797-800
pubmed:dateRevised
2008-5-7
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Cerebrospinal fluid oligoclonal bands and progression of disability in multiple sclerosis.
pubmed:affiliation
Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. m.w.koch@neuro.umcg.nl
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't