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pubmed:abstractText |
Cyclooxygenase (COX)-2 is an inducible isoform responsive to cytokines, mitogens, and growth factors, and is believed to be an important enzyme related to colorectal cancer (CRC). Existing evidence suggests that COX-2 expression is normally suppressed by wild-type p53 but not mutant p53, suggesting that loss of p53 function may result in the induction of COX-2 expression. The aim of this study was to determine the relationship between COX-2 expression and p53 levels in CRC.
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pubmed:affiliation |
Department of Surgery, Chosun University College of Medicine, 375 Seosuk- dong, Dong-gu, Gwangju 501-759, Korea.
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