Source:http://linkedlifedata.com/resource/pubmed/id/17594108
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2007-7-13
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| pubmed:abstractText |
Microvessel density (MVD) is considered to be a prognostic marker in many tumours. Nevertheless, conflicting results were achieved regarding its prognostic role in meningiomas when it was quantified through pan-endothelial markers such as CD34, CD31 or Factor VIII. In the present study, MVD was assessed in meningiomas through the specific marker for neo-angiogenesis CD105. Fifty-four formalin fixed, paraffin embedded, surgical cases of meningiomas (WHO 28 grade I and 26 grade II) as well as ten normal leptomeningeal samples were submitted to immunohistochemical analysis for CD105. CD34 immuno-expression was also evaluated on consecutive parallel sections. For each case, MVD was estimated in terms of number of vessels/mm(2). CD105 was not evidenced in normal samples, whereas it was demonstrated in the vessels within 14/28 WHO grade I cases and within 24/26 WHO grade II meningiomas. On the contrary, CD34 antibody stained blood vessels in both normal and neoplastic samples; moreover, in each case, it stained more microvessels than CD105 antibody (25.33 +/- 21.16 vs. 50.72 +/- 26.75). Higher CD105 counts were significantly correlated with higher histological grade and Ki-67 LI > 4%. No statistical significant correlations were encountered between MVD measured by either CD105 and CD34 and sex, age, site of tumour or extent of surgical resection. CD105-MVD, but not CD34-MVD, showed an inverse significant correlation with overall survival and recurrence-free survival. In conclusion, our study suggests the higher specificity of CD105 in comparison to pan-endothelial markers in the evaluation of meningioma neo-angiogenesis, and its higher prognostic significance. CD105 might serve as a target for therapeutic approaches blocking blood supply in meningiomas.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD34,
http://linkedlifedata.com/resource/pubmed/chemical/ENG protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological
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| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
0001-6322
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
114
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
147-56
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| pubmed:dateRevised |
2010-11-18
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| pubmed:meshHeading |
pubmed-meshheading:17594108-Adult,
pubmed-meshheading:17594108-Aged,
pubmed-meshheading:17594108-Aged, 80 and over,
pubmed-meshheading:17594108-Antigens, CD,
pubmed-meshheading:17594108-Antigens, CD34,
pubmed-meshheading:17594108-Capillaries,
pubmed-meshheading:17594108-Female,
pubmed-meshheading:17594108-Humans,
pubmed-meshheading:17594108-Immunohistochemistry,
pubmed-meshheading:17594108-Kaplan-Meier Estimate,
pubmed-meshheading:17594108-Male,
pubmed-meshheading:17594108-Meningeal Neoplasms,
pubmed-meshheading:17594108-Meningioma,
pubmed-meshheading:17594108-Middle Aged,
pubmed-meshheading:17594108-Neovascularization, Pathologic,
pubmed-meshheading:17594108-Prognosis,
pubmed-meshheading:17594108-Receptors, Cell Surface,
pubmed-meshheading:17594108-Sensitivity and Specificity,
pubmed-meshheading:17594108-Tumor Markers, Biological
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| pubmed:year |
2007
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| pubmed:articleTitle |
Density of microvessels positive for CD105 (endoglin) is related to prognosis in meningiomas.
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| pubmed:affiliation |
Dipartimento di Patologia Umana, University of Messina, Messina, Italy. valeriabarresi@hotmail.com
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| pubmed:publicationType |
Journal Article
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