Source:http://linkedlifedata.com/resource/pubmed/id/17593860
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2007-6-27
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| pubmed:abstractText |
Polymorphism (variable number of tandem repeats) in the second intron of the interleukin-1 receptor antagonist (IL-1Ra) gene and two single nucleotide polymorphisms at positions -511 and +3954 of the IL-1beta gene may be associated with an increased risk of rheumatoid arthritis (RA). This study used sex stratification to investigate a correlation of the three genetic polymorphisms with the risk of RA, on patients with RA and healthy controls. Polymerase chain reaction (PCR) and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) were performed. The frequencies of the IL-1beta+3954 allele and genotype in female patients were significantly different compared with the controls; but in males, only the frequency of the IL-1beta+3954 allele was different. The frequency of the IL-1RN genotype in patients was not statistically different compared with the controls; however, the frequency of IL-1RN allele in female patients was different. The association of the three polymorphisms with the susceptibility to RA appears to be significantly affected by gender.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
0300-0605
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
35
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
323-8
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| pubmed:dateRevised |
2007-9-20
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| pubmed:meshHeading |
pubmed-meshheading:17593860-Adult,
pubmed-meshheading:17593860-Aged,
pubmed-meshheading:17593860-Arthritis, Rheumatoid,
pubmed-meshheading:17593860-Asian Continental Ancestry Group,
pubmed-meshheading:17593860-Case-Control Studies,
pubmed-meshheading:17593860-China,
pubmed-meshheading:17593860-Female,
pubmed-meshheading:17593860-Gene Frequency,
pubmed-meshheading:17593860-Genetic Predisposition to Disease,
pubmed-meshheading:17593860-Genetics, Population,
pubmed-meshheading:17593860-Humans,
pubmed-meshheading:17593860-Interleukin 1 Receptor Antagonist Protein,
pubmed-meshheading:17593860-Interleukin-1beta,
pubmed-meshheading:17593860-Male,
pubmed-meshheading:17593860-Middle Aged,
pubmed-meshheading:17593860-Polymorphism, Genetic,
pubmed-meshheading:17593860-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:17593860-Receptors, Interleukin-1,
pubmed-meshheading:17593860-Sex Factors
|
| pubmed:articleTitle |
Sex influences on the penetrance of IL-1beta and IL-1RN genotypes for rheumatoid arthritis in the Chinese population.
|
| pubmed:affiliation |
School of Life Sciences, Lanzhou University, Lanzhou City, China.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|