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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2007-6-26
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pubmed:abstractText |
A significant increase/decrease in uterine and ovarian weights was occasionally seen in immature mice and rats subcutaneously administered paradichlorobenzene (PDCB) at doses of 22-67 mg/kg/day, but the results were not necessarily reproducible. PDCB at a dose of 800 mg/kg/day always reduced uterine and ovarian weights. Intraperitoneal PDCB at doses more than 400 mg/kg/day significantly inhibited the uterotrophic effect of beta-estradiol (E2) in CD-1 (ICR) mice. E2-induced uterotrophy was dose-dependently prevented by 204-400 mg PDCB/kg/day in C57BL/6N (Ah responsive) mice but not DBA/2N (Ah non-responsive) mice. While PDCB did not bind to estrogen receptor (ER(alpha)) up to 10(-3) M. Hepatic ethoxyresorufin-O-deethylase in adult female C57BL/6N mice was induced by i.p. administration of PDCB. Induction activity of PDCB may be 10(5)-10(6) times lower than that of 2,3,7,8-tetrachlorodibenzo-p-dioxin. These results suggest that PDCB is a weak antiestrogenic/antiuterotrophic compound possibly due to ER modulation through arylhydrocarbon receptor.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4-dichlorobenzene,
http://linkedlifedata.com/resource/pubmed/chemical/Ahr protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Basic Helix-Loop-Helix...,
http://linkedlifedata.com/resource/pubmed/chemical/Chlorobenzenes,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP1A1,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP2B1,
http://linkedlifedata.com/resource/pubmed/chemical/Endocrine Disruptors,
http://linkedlifedata.com/resource/pubmed/chemical/Estradiol,
http://linkedlifedata.com/resource/pubmed/chemical/Estrogen Receptor Modulators,
http://linkedlifedata.com/resource/pubmed/chemical/Estrogen Receptor alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Peroxidase,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Aryl Hydrocarbon,
http://linkedlifedata.com/resource/pubmed/chemical/Tretinoin
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0340-5761
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
505-17
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:17593412-Animals,
pubmed-meshheading:17593412-Basic Helix-Loop-Helix Transcription Factors,
pubmed-meshheading:17593412-Chlorobenzenes,
pubmed-meshheading:17593412-Cytochrome P-450 CYP1A1,
pubmed-meshheading:17593412-Cytochrome P-450 CYP2B1,
pubmed-meshheading:17593412-Dose-Response Relationship, Drug,
pubmed-meshheading:17593412-Endocrine Disruptors,
pubmed-meshheading:17593412-Enzyme Induction,
pubmed-meshheading:17593412-Estradiol,
pubmed-meshheading:17593412-Estrogen Receptor Modulators,
pubmed-meshheading:17593412-Estrogen Receptor alpha,
pubmed-meshheading:17593412-Female,
pubmed-meshheading:17593412-Liver,
pubmed-meshheading:17593412-Mice,
pubmed-meshheading:17593412-Mice, Inbred C57BL,
pubmed-meshheading:17593412-Mice, Inbred DBA,
pubmed-meshheading:17593412-Mice, Inbred ICR,
pubmed-meshheading:17593412-Organ Size,
pubmed-meshheading:17593412-Ovary,
pubmed-meshheading:17593412-Peroxidase,
pubmed-meshheading:17593412-Rats,
pubmed-meshheading:17593412-Rats, Sprague-Dawley,
pubmed-meshheading:17593412-Receptors, Aryl Hydrocarbon,
pubmed-meshheading:17593412-Reproducibility of Results,
pubmed-meshheading:17593412-Species Specificity,
pubmed-meshheading:17593412-Tretinoin,
pubmed-meshheading:17593412-Uterus
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pubmed:year |
2007
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pubmed:articleTitle |
Antiestrogenic effect of paradichlorobenzene in immature mice and rats.
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pubmed:affiliation |
Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health, 24-1 Hyakunincho 3-chome, Shinjuku-ku, Tokyo, 169-0073, Japan. osamu_takahashi@member.metro.tokyo.jp
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pubmed:publicationType |
Journal Article
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