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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2007-8-16
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pubmed:abstractText |
Inhibition of HERG channels prolongs the ventricular action potential and the QT interval with the risk of torsade de pointes arrhythmias and sudden cardiac death. Many drugs induce greater inhibition of HERG channels when the cell membrane is depolarized frequently. The dependence of inhibition on the pulsing rate may yield different IC(50) values at different frequencies and thus affect the quantification of HERG channel block. We systematically compared the kinetics of HERG channel inhibition and recovery from block by 8 blockers at different frequencies.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17592502-10208308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17592502-10325236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17592502-10394001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17592502-10510456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17592502-10742304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17592502-11239413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17592502-11339975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17592502-11343409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17592502-12460639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17592502-12618227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17592502-12667944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17592502-12747773,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17592502-12776219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17592502-1501123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17592502-15189761,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17592502-15308760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17592502-15385083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17592502-15389727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17592502-15637086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17592502-15722405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17592502-15749156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17592502-15778703,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17592502-16474003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17592502-5112659,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17592502-7604285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17592502-7736582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17592502-7889573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17592502-8562085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17592502-8641472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17592502-9138706
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
151
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1368-76
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17592502-Action Potentials,
pubmed-meshheading:17592502-Animals,
pubmed-meshheading:17592502-Arrhythmias, Cardiac,
pubmed-meshheading:17592502-Dose-Response Relationship, Drug,
pubmed-meshheading:17592502-Electric Stimulation,
pubmed-meshheading:17592502-Ether-A-Go-Go Potassium Channels,
pubmed-meshheading:17592502-Heart Ventricles,
pubmed-meshheading:17592502-Humans,
pubmed-meshheading:17592502-Inhibitory Concentration 50,
pubmed-meshheading:17592502-Kinetics,
pubmed-meshheading:17592502-Mutation,
pubmed-meshheading:17592502-Oocytes,
pubmed-meshheading:17592502-Patch-Clamp Techniques,
pubmed-meshheading:17592502-Xenopus
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pubmed:year |
2007
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pubmed:articleTitle |
State dependent dissociation of HERG channel inhibitors.
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pubmed:affiliation |
Department of Pharmacology and Toxicology, University of Vienna, Althanstrasse 14, Vienna 1090, Austria.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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