| pubmed-article:17592038 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17592038 | lifeskim:mentions | umls-concept:C1101610 | lld:lifeskim |
| pubmed-article:17592038 | lifeskim:mentions | umls-concept:C0204727 | lld:lifeskim |
| pubmed-article:17592038 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:17592038 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:17592038 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:17592038 | pubmed:dateCreated | 2007-7-19 | lld:pubmed |
| pubmed-article:17592038 | pubmed:abstractText | microRNAs (miRNAs) serve as post-transcriptional regulators of gene expression, by guiding effector complexes (miRNPs) to target RNAs. Although considerable progress has been made in computational methods to identify miRNA targets, only a relatively limited assessment of their ability to function in vivo has been reported. Here we describe an alternative approach to miRNA target identification based on a biochemical method for purifying miRNP complexes with associated miRNAs and bound mRNA targets. Microarray analysis revealed a high degree of enrichment for miRNA complementary sites in the 3'UTRs of the miRNP-associated mRNAs. mRNAs specifically associated with an individual miRNA were identified by comparing the miRNP-associated mRNAs from wild-type flies and mutant flies lacking miR-1, and their regulation by the miRNA was validated. This approach provides a means to identify functional miRNA targets based on their physical interaction in vivo. | lld:pubmed |
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| pubmed-article:17592038 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17592038 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17592038 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17592038 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17592038 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:17592038 | pubmed:issn | 1355-8382 | lld:pubmed |
| pubmed-article:17592038 | pubmed:author | pubmed-author:CohenStephen... | lld:pubmed |
| pubmed-article:17592038 | pubmed:author | pubmed-author:TelemanAureli... | lld:pubmed |
| pubmed-article:17592038 | pubmed:author | pubmed-author:EasowGeorgeG | lld:pubmed |
| pubmed-article:17592038 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17592038 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:17592038 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17592038 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17592038 | pubmed:pagination | 1198-204 | lld:pubmed |
| pubmed-article:17592038 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:17592038 | pubmed:meshHeading | pubmed-meshheading:17592038... | lld:pubmed |
| pubmed-article:17592038 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17592038 | pubmed:articleTitle | Isolation of microRNA targets by miRNP immunopurification. | lld:pubmed |
| pubmed-article:17592038 | pubmed:affiliation | European Molecular Biology Laboratory, Heidelberg, Germany. | lld:pubmed |
| pubmed-article:17592038 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17592038 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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